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Artificial intelligence in tuberculosis: a new ally in disease control.
Breathe (Sheff)
October 2024
Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Munich, Germany.
The challenges to effective tuberculosis (TB) disease control are considerable, and the current global targets for reductions in disease burden seem unattainable. The combination of complex pathophysiology and technical limitations results in difficulties in achieving consistent, reliable diagnoses, and long treatment regimens imply serious physiological and socioeconomic consequences for patients. Artificial intelligence (AI) applications in healthcare have significantly improved patient care regarding diagnostics, treatment and basic research.
View Article and Find Full Text PDFAmplification of oxidative stress by lipid surface-coated single-atom Au nanozymes for oral cancer photodynamic therapy.
Nanoscale
October 2023
Department of Chemistry, National Taiwan University, Taipei, 10617, Taiwan.
Single-atom nanozymes (SANs) are the latest trend in biomaterials research and promote the application of single atoms in biological fields and the realization of protein catalysis with inorganic nanoparticles. Carbon quantum dots (CDs) have excellent biocompatibility and fluorescence properties as a substrate carrying a single atom. It is difficult to break through pure-phase single-atom materials with quantum dots as carriers.
View Article and Find Full Text PDFCorrelative Fluorescence and Transmission Electron Microscopy Assisted by 3D Machine Learning Reveals Thin Nanodiamonds Fluoresce Brighter.
ACS Nano
September 2023
School of Materials Science and Engineering, University of New South Wales, Sydney, NSW 2052, Australia.
Nitrogen vacancy (NV) centers in fluorescent nanodiamonds (FNDs) draw widespread attention as quantum sensors due to their room-temperature luminescence, exceptional photo- and chemical stability, and biocompatibility. For bioscience applications, NV centers in FNDs offer high-spatial-resolution capabilities that are unparalleled by other solid-state nanoparticle emitters. On the other hand, pursuits to further improve the optical properties of FNDs have reached a bottleneck, with intense debate in the literature over which of the many factors are most pertinent.
View Article and Find Full Text PDFRolling out new anti-tuberculosis drugs without diagnostic capacity.
Breathe (Sheff)
June 2023
IRCCS San Raffaele Scientific Institute, Milan, Italy.
Deaths from tuberculosis (TB) reached over 1.6 million in 2021 with 10.6 million people becoming ill.
View Article and Find Full Text PDFFibroblasts Drive Metabolic Reprogramming in Pacemaker Cardiomyocytes.
Circ Res
June 2022
Division of Cardiology, Department of Medicine, Heart Rhythm Center (P.-C.C., C.-M.L., C.-H.W., J.-D.L., Y.-F.H.), Taipei Veterans General Hospital, Taiwan.
Background: The sino atrial node (SAN) is characterized by the microenvironment of pacemaker cardiomyocytes (PCs) encased with fibroblasts. An altered microenvironment leads to rhythm failure. Operable cell or tissue models are either generally lacking or difficult to handle.
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