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| http://dx.doi.org/10.1128/mr.51.4.439-457.1987 | DOI Listing |
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The mycobacterial ABC transporter IrtAB employs a membrane-facing crevice for siderophore-mediated iron uptake.
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Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
The mycobacterial ABC transporter IrtAB features an ABC exporter fold, yet it imports iron-charged siderophores called mycobactins. Here, we present extensive cryo-EM analyses and DEER measurements, revealing that IrtAB alternates between an inward-facing and an outward-occluded conformation, but does not sample an outward-facing conformation. When IrtAB is locked in its outward-occluded conformation in nanodiscs, mycobactin is bound in the middle of the lipid bilayer at a membrane-facing crevice opening at the heterodimeric interface.
View Article and Find Full Text PDFHuman-derived microRNA 21 regulates indole and L-tryptophan biosynthesis transcripts in the gut commensal .
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Centre for Microbiology and Environmental Systems Science, Department of Microbiology and Ecosystem Science, Division of Microbial Ecology, University of Vienna, Vienna, Austria.
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View Article and Find Full Text PDFBackground Tuberculosis (TB) remains a major cause of global morbidity and mortality. Efforts to control TB are hampered by the lengthy and cumbersome treatment required to eradicate the infection. Bacterial persistence during exposure to bactericidal antibiotics is at least partially mediated by the bacterial stringent response enzyme, Rel .
View Article and Find Full Text PDFBacterial activation level determines Cd(II) immobilization efficiency by calcium-phosphate minerals in soil.
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National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, PR China. Electronic address:
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Servei de Microbiologia i Parasitologia-CDB, Hospital Clínic de Barcelona, Barcelona, Spain.
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