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| http://dx.doi.org/10.1016/j.bj.2020.10.006 | DOI Listing |
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Melatonin supplementation to sows in mid to late gestation affects offspring circadian, myogenic, and growth factor transcript abundance in pre and postnatal skeletal muscle.
J Anim Sci
January 2024
Department of Animal and Dairy Sciences, Mississippi State University, Starkville, MS 39762, USA.
The neuroendocrine hormone melatonin is associated with circadian rhythms and has antioxidant and vasodilative properties. In cattle, melatonin rescues fetal growth during maternal nutrient restriction in a seasonally dependent manner, but melatonin research in swine is limited. The objective of this study was to evaluate the effects of dietary melatonin supplementation during mid to late gestation on circadian rhythm and muscle growth and development of the longissimus dorsi in utero and postnatally.
View Article and Find Full Text PDFMelatonin Attenuates PFOS-Induced Reproductive Toxicity of Pregnant Mice due to Placental Damage Via Antioxidant, Anti-Aging and Anti-Inflammatory Pathways.
Birth Defects Res
December 2024
Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Background: Perfluorooctane sulfonate (PFOS), an industrially synthesized persistent organic pollutant (POP), is intricately intertwined with human production and daily life. It has been discovered that PFOS is related to an elevated incidence of birth defects in fetuses. In contrast, melatonin (MLT), a hormone secreted by the pineal gland, has been demonstrated to exert a protective effect on reproductive development.
View Article and Find Full Text PDFSex-Specific Metabolic Effects of Gestational Chronodisruption and Maternal Melatonin Supplementation in Rat Offspring.
J Pineal Res
November 2024
Laboratory of Developmental Chronobiology, Instituto de Anatomía, Histología y Patología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile.
Gestational chronodisruption, increasingly common due to irregular light exposure, disrupts maternal-fetal circadian signaling, leading to long-term health issues in offspring. We utilized a chronic photoperiod shifting model (CPS) in pregnant rats to induce chronodisruption and investigated the potential mitigating effects of maternal melatonin supplementation (CPS + Mel). Male and female offspring were evaluated at 3 ages (90, 200, and 400 days of age) for metabolic profiles, hormonal responses, cytokine levels, and adipose tissue activity.
View Article and Find Full Text PDFEffect of melatonin treatment of pregnant Sarda ewes on lactation and lamb development.
Reprod Fertil Dev
December 2024
Department of Veterinary Medicine of Sassari, University of Sassari, Via Vienna 2, Sassari 07100, Italy.
Context Melatonin administration during pregnancy can influence fetal development and lactation. Aims This study aimed to verify whether melatonin treatment of pregnant Sarda ewes in spring improved lamb weight at birth, 7 and 21days of age, time to first colostrum intake, birth behavior and survival. Additionally, we examined melatonin's effect on milk yield and composition.
View Article and Find Full Text PDFThe Use of Antioxidants for Cardiovascular Protection in Fetal Growth Restriction: A Systematic Review.
Antioxidants (Basel)
November 2024
The Ritchie Centre, Hudson Institute of Medical Research, 27-31 Wright Street, Clayton 3168, Australia.
Article Synopsis
- Fetal growth restriction (FGR) is linked to higher cardiovascular disease risk, with no current treatments; however, antioxidants may offer a solution.
- A systematic review analyzed studies on antenatal antioxidant interventions for cardiovascular outcomes in FGR, finding that 71% of studies reported improvement and over half showed strong cardiovascular protection.
- Among 15 antioxidants studied, melatonin was most prevalent, and all examined methods demonstrated the restoration of endothelial function and reduction of oxidative stress.
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