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Retrospective Cohort Study of Associated Factors for Intestinal Complications in Pediatric Liver Transplantation.
Pediatr Transplant
December 2024
Swiss Pediatric Liver Center, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland.
Background: Intestinal complications (IC) represent serious adverse events after liver transplantation (LT), however limited research has been conducted in pediatric cohorts. This study aims to describe IC after pediatric LT and to identify associated factors.
Methods: Retrospective review of 153 patients having undergone LT, aged 0-18 years, treated in the Swiss Pediatric Liver Center in Geneva.
A case series of prenatal hepatic hilar cyst in the presence of a gallbladder - navigating the dilemma between biliary atresia and choledochal cyst.
BMC Pediatr
September 2024
Swiss Pediatric Liver Center, Department of Pediatrics, Gynecology and Obstetrics, University of Geneva, Geneva, Switzerland.
Background: Prenatally diagnosed hepatic hilar cysts are a challenging finding for the clinician. They can either be a sign of cystic biliary atresia (BA) or a choledochal cyst (CC), two diagnoses with different postnatal management and prognosis. Based on a case report of four patients, we aim to propose a management algorithm for prenatally diagnosed "hepatic hilar cysts".
View Article and Find Full Text PDFArticle Synopsis
- In 2022, the Biliary Atresia and Related Diseases (BARD) community developed a standardized definition for diagnosing cholangitis in biliary atresia (BA) patients, which was then assessed in a study involving data from 2010 to 2020 at two medical centers.
- The study found that out of 185 BA patients, 32% experienced at least one episode of cholangitis in the first year after surgery, and there was a strong correlation (0.8) between the new standardized definition and the doctors' clinical diagnoses.
- The results indicate that while the standardized definition coincided closely with clinicians' assessments, a prospective study is recommended to further refine this definition for better future diagnoses.
Rituximab-to-vaccine interval on SARS-CoV-2 immunogenicity in children: The potential role of prior natural infection.
Pediatr Allergy Immunol
May 2024
Unit of Immunology, Vaccinology and Rheumatology, Division of General Pediatrics, Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals, Geneva, Switzerland.
Background: Treatment with anti-CD20 antibodies (rituximab) is used in both adults and children to treat various autoimmune and oncological diseases. Rituximab depletes B CD20+ cells and, thereby, antibody response to vaccines. This study aimed to examine the antibody response to mRNA-based COVID-19 vaccines in children aged 5-18 years undergoing rituximab treatment compared to healthy matched children.
View Article and Find Full Text PDFPredictors for pathological bone fractures in children undergoing liver transplantation: A retrospective cohort study.
Pediatr Transplant
May 2024
Department of Pediatrics, Gynecology, and Obstetrics, Swiss Pediatric Liver Center, University of Geneva, University Hospitals of Geneva, Geneva, Switzerland.
Background: Hepatic osteodystrophy refers to bone disorders associated with chronic liver disease, including children undergoing liver transplantation (LT). The aim of this study was to quantify the prevalence of pathological fractures (PF) in children before and after LT and to identify associated factors for their occurrence.
Methods: Children aged 0-18 years who underwent LT from 1/2005 to 12/2020 were included in this retrospective study.
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