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Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study. | LitMetric

AI Article Synopsis

  • The study investigates how different glucose curves observed in a mixed-meal tolerance test can explain the variations in characteristics and outcomes of individuals with type 2 diabetes (T2D).
  • It involved 787 newly diagnosed T2D patients and identified three distinct glucose curve subgroups, with the higher peak groups (subgroups 2 and 3) showing worse metabolic traits like elevated HbA1c, triglycerides, and BMI compared to subgroup 1.
  • Over 18 months, those in the higher peak groups experienced greater worsening in their HbA1c, triglycerides, and fasting glucose levels, indicating a higher metabolic risk associated with these profiles.

Article Abstract

Aim: Subclasses of different glycaemic disturbances could explain the variation in characteristics of individuals with type 2 diabetes (T2D). We aimed to examine the association between subgroups based on their glucose curves during a five-point mixed-meal tolerance test (MMT) and metabolic traits at baseline and glycaemic deterioration in individuals with T2D.

Methods: The study included 787 individuals with newly diagnosed T2D from the Diabetes Research on Patient Stratification (IMI-DIRECT) Study. Latent class trajectory analysis (LCTA) was used to identify distinct glucose curve subgroups during a five-point MMT. Using general linear models, these subgroups were associated with metabolic traits at baseline and after 18 months of follow up, adjusted for potential confounders.

Results: At baseline, we identified three glucose curve subgroups, labelled in order of increasing glucose peak levels as subgroup 1-3. Individuals in subgroup 2 and 3 were more likely to have higher levels of HbA1c, triglycerides and BMI at baseline, compared to those in subgroup 1. At 18 months (n = 651), the beta coefficients (95% CI) for change in HbA1c (mmol/mol) increased across subgroups with 0.37 (-0.18-1.92) for subgroup 2 and 1.88 (-0.08-3.85) for subgroup 3, relative to subgroup 1. The same trend was observed for change in levels of triglycerides and fasting glucose.

Conclusions: Different glycaemic profiles with different metabolic traits and different degrees of subsequent glycaemic deterioration can be identified using data from a frequently sampled mixed-meal tolerance test in individuals with T2D. Subgroups with the highest peaks had greater metabolic risk.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703960PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242360PLOS

Publication Analysis

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