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| http://dx.doi.org/10.1016/j.ciresp.2020.10.012 | DOI Listing |
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Functional contribution of sphingosine-1-phosphate to airway pathology in cigarette smoke-exposed mice.
Br J Pharmacol
January 2020
Department of Pharmacy, University of Naples Federico II, Naples, Italy.
Article Synopsis
- The study investigates the role of the sphingosine kinase/sphingosine-1-phosphate (S1P) pathway in chronic obstructive pulmonary disease (COPD) using a mouse model exposed to cigarette smoke.
- Mice exposed to smoke showed lung damage, increased airway reactivity, and elevated levels of S1P and its receptors, indicating a link between smoking and airway hyperresponsiveness.
- The findings suggest that targeting S1P signaling could be a potential therapeutic strategy for treating airway issues in smokers with conditions like asthma and COPD.
CT-Based Local Distribution Metric Improves Characterization of COPD.
Sci Rep
June 2017
Department of Radiology, University of Michigan, Center for Molecular Imaging, Ann Arbor, MI, United States.
Parametric response mapping (PRM) of paired CT lung images has been shown to improve the phenotyping of COPD by allowing for the visualization and quantification of non-emphysematous air trapping component, referred to as functional small airways disease (fSAD). Although promising, large variability in the standard method for analyzing PRM has been observed. We postulate that representing the 3D PRM data as a single scalar quantity (relative volume of PRM) oversimplifies the original 3D data, limiting its potential to detect the subtle progression of COPD as well as varying subtypes.
View Article and Find Full Text PDFAMP-activated protein kinase reduces inflammatory responses and cellular senescence in pulmonary emphysema.
Oncotarget
April 2017
School of Pharmacy, Anhui Medical University, Hefei, The People's Republic of China.
Current drug therapy fails to reduce lung destruction of chronic obstructive pulmonary disease (COPD). AMP-activated protein kinase (AMPK) has emerged as an important integrator of signals that control energy balance and lipid metabolism. However, there are no studies regarding the role of AMPK in reducing inflammatory responses and cellular senescence during the development of emphysema.
View Article and Find Full Text PDFParametric response mapping on chest computed tomography associates with clinical and functional parameters in chronic obstructive pulmonary disease.
Respir Med
February 2017
Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Background: In the search for specific phenotypes of chronic obstructive pulmonary disease (COPD) computed tomography (CT) derived Parametric Response Mapping (PRM) has been introduced. This study evaluates the association between PRM and currently available biomarkers of disease severity in COPD.
Methods: Smokers with and without COPD were characterized based on questionnaires, pulmonary function tests, body plethysmography, and low-dose chest CT scanning.
Dexpanthenol therapy reduces lung damage in a hyperoxic lung injury in neonatal rats.
J Matern Fetal Neonatal Med
January 2017
a Division of Neonatology, Department of Pediatrics , Inonu University School of Medicine, Malatya , Turkey .
Objective: Dexpanthenol (Dxp) plays a major role in cellular defense and in repair systems against oxidative stress and inflammatory response and it has not yet been evaluated in treatment of bronchopulmonary dysplasia (BPD). We tested the hypothesis that proposes whether Dxp decreases the severity of lung injury in an animal model of BPD.
Methods: Forty rat pups were divided into four groups: control, control + Dxp, hyperoxia and hyperoxia + Dxp.
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