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Tertiary Lymphoid Structures and B cells: Clinical impact and therapeutic modulation in cancer. | LitMetric

Tertiary Lymphoid Structures and B cells: Clinical impact and therapeutic modulation in cancer.

Semin Immunol

Centre de Recherche des Cordeliers, Sorbonne Université, Inserm, Université de Paris, F-75006, Paris, France; Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006, Paris, France.

Published: April 2020

AI Article Synopsis

Article Abstract

Tumors progression is under the control of a heterogeneous microenvironment composed of immune cells, fibroblasts, blood and lymphatic vessels, in which T cells have been demonstrated to be major actors, through their cytotoxic and cytokine producing effector functions and their long term memory that protects against metastasis. In this scenario, lessons from mouse models taught that B cells exert a protumoral role, via macrophage-dependent activation of inflammation. However, it became progressively evident from studies in patients with human cancers that the anti-tumor responses can be generated and controlled in tertiary lymphoid structures (TLS) that concentrate most of the intratumoral B cells and where B cells can differentiate into plasma cells and memory cells. Furthermore, recent studies demonstrated that the presence in tumors of B cells and TLS are associated with favorable outcome in patients treated by immunotherapy, unraveling TLS as a new predictive marker of anti-tumor response human cancers. This review encompasses the characteristics and functions of TLS and of B cells in human tumors, their prognostic and theranostic impact and summarizes the mouse models used to induce TLS neogenesis in tumors.

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Source
http://dx.doi.org/10.1016/j.smim.2020.101406DOI Listing

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