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[Efficient treatment of mild Crohn's disease and mild ulcerative colitis].
Inn Med (Heidelb)
December 2024
Klinik für Gastroenterologie und Hepatologie, Universitätsspital Zürich, Rämistrasse 100, 8091, Zürich, Schweiz.
The cornerstone of treatment for mild ulcerative colitis is still the oral or topical (rectal) application of aminosalicylates (5-ASA). 5‑ASA preparations are often only administered orally in mild ulcerative colitis. Study data show that in ulcerative proctitis and left-sided colitis, rectal 5‑ASA preparations are even more effective than oral administration.
View Article and Find Full Text PDFEvolution of Eligibility Criteria in Inflammatory Bowel Disease Clinical Trials: A Clinical Trial Databank Analysis.
United European Gastroenterol J
December 2024
Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium.
Background: Eligibility criteria in clinical trials have been criticised for being overly restrictive without clinical justification.
Objective: We aimed to investigate the types, evolution, and current status of eligibility criteria in clinical trials for inflammatory bowel diseases (IBD).
Methods: We performed a clinical trial databank search on clinicaltrials.
Sex-related differences in profiles and clinical outcomes of Inflammatory bowel disease: a systematic review and meta-analysis.
BMC Gastroenterol
November 2024
Consultant Internal Medicine and Gastroenterology, European Gaza Hospital, Gaza, Palestine.
Article Synopsis
- * The systematic review included 44 studies and found that females experience higher rates of anxiety and depression, have worse quality of life scores, and are less likely to have certain complications compared to males, who have a higher mortality risk and require more surgeries.
- * Overall, males and females show some differences in mental health and disease management, but no significant variations were noted in hospitalization rates or the overall behavior of the disease.
Rubella myopericarditis and cardiac tamponade: a case report.
Oxf Med Case Reports
November 2024
Department of Cardiology, NHO Takasaki General Medical Center, Takasaki, Japan.
A 20-year-old male patient with ulcerative proctitis presented with a fever and chest pain. He was diagnosed with rubella-associated myopericarditis due to pericardial rub, elevated troponin I, ST elevation, and positive rubella-immunoglobulin M. The patient subsequently developed cardiac tamponade but responded well to pericardial drainage and antiinflammatory therapy.
View Article and Find Full Text PDFReal-World Effectiveness and Safety of Carotegrast Methyl in Japanese Patients with Moderately Active Ulcerative Colitis.
Inflamm Intest Dis
October 2024
Department of Gastroenterology, Ohmori Toshihide Gastro-intestinal Clinic, Ageo, Saitama, Japan.
Article Synopsis
- Carotegrast methyl (CGM) is a newly approved oral medication in Japan for treating moderately active ulcerative colitis (UC) in patients who don’t respond well to traditional treatments like 5-aminosalicylates.
- A study involving 14 Japanese patients showed that CGM led to significant endoscopic improvement in 64% of cases, with many experiencing reduced symptoms like diarrhea and abdominal pain after treatment.
- The study concluded that CGM appears to be a safe and effective option for inducing remission in patients with UC, with no reported serious side effects during the observation period.
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