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| http://dx.doi.org/10.1007/s00105-020-04733-w | DOI Listing |
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Paradoxical reaction under dupilumab triggered by occasional ketoprofen intake.
Dermatol Reports
February 2025
Dermatology Unit & Scientific Directorate, Galliera Hospital, Genoa.
Dupilumab, a monoclonal antibody targeting the IL-4/13 signaling pathway, effectively treats moderate-to-severe atopic dermatitis (AD). Common side effects include injection site reactions, conjunctivitis, and respiratory infections. We report the case of a 28-year-old woman with severe AD involving the periocular and chin regions, genital areas, arms, and legs (Eczema Area and Severity Index [EASI]: 24, itch Visual Analog Scale [VAS]: 8) who showed significant improvement after initiating dupilumab therapy.
View Article and Find Full Text PDFCase report: Toxic epidermal necrolysis as a unique presentation of acute graft versus host disease in a pediatric patient.
Front Immunol
February 2025
Pediatric Hematology Oncology and Stem Cell Transplant, Riley Hospital for Children at Indiana University (IU) Health, Indiana University School of Medicine, Indianapolis, IN, United States.
Introduction: Acute graft versus host disease (aGVHD) is a common complication of stem cell transplant (SCT), with skin involvement being most common. Severe presentations of skin aGVHD involving rapid progression of rash to bullae formation and mucosal involvement are rare. There are reports of patients with skin aGVHD that present with clinical characteristics mimicking toxic epidermal necrolysis (TEN), suggesting a possible overlap between the two.
View Article and Find Full Text PDFUltrasonographic evaluation of acute idiopathic scrotal wall oedema in adults.
BMJ Case Rep
February 2025
Radiodiagnosis, Datta Meghe Institute of Higher Education & Research, Wardha, Maharashtra, India.
Acute idiopathic scrotal wall oedema is an uncommon cause of acute scrotal oedema that usually affects the paediatric population and is rarely encountered in adults. It frequently goes away without the need for surgery, presenting as sudden scrotal oedema and erythema. Acute idiopathic scrotal wall oedema is diagnosed and distinguished from other scrotal disorders by clinical examination and ultrasonography, which includes the distinctive 'fountain sign'.
View Article and Find Full Text PDFUrethral Complications Due to Erythema Multiforme Major: A Case Report.
Cureus
December 2024
Department of Anatomy, A.T. Still University of Health Sciences - Kirksville College of Osteopathic Medicine, Kirksville, USA.
Erythema multiforme major (EMM) is an acute, immune-mediated mucocutaneous disease that rarely affects the genital mucosal surfaces. This study describes a 39-year-old male with this rare disease and unusual presentation. The patient presented to an emergency department with oral lesions, drainage from both eyes, injected sclera, and characteristic targetoid lesions on the face, upper extremities, torso, and plantar surfaces of the feet.
View Article and Find Full Text PDFFulminant non-traumatic Clostridium perfringens necrotizing fasciitis and myonecrosis in a child with acute myeloid leukemia.
J Infect Public Health
March 2025
Department of Pediatric Infectious Diseases, Ministry of National Guard-Health Affairs (MNGHA), King Abdullah Specialist Children Hospital, Riyadh, Saudi Arabia; King Abdullah International Medical Research Centre, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia; Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City (KAMC), MNGHA, Riyadh, Saudi Arabia.
Necrotizing fasciitis is a potentially life-threatening infection that can lead to rapid muscular and fascial necrosis, often resulting in sepsis. In addition to the rapid disease progression, diagnosing this disease in children can be challenging as they cannot accurately communicate their symptoms. Spontaneous necrotizing fasciitis secondary to Clostridial infection has rarely been described in the literature but occurs in neutropenic patients with significant morbidity and mortality from myonecrosis and gas gangrene.
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