AI Article Synopsis
- * It covers the current knowledge regarding the types of ligands, the techniques used for functionalizing these nanocarriers, and the methods for purifying them after the ligands are attached.
- * Additionally, the review highlights key experimental techniques for analyzing the surface of LBNCs, including advanced methods like nuclear magnetic resonance spectroscopy and isothermal titration calorimetry for studying the ligand attachment.
Article Abstract
Surface functionalization of lipid-based nanocarriers (LBNCs) with targeting ligands has attracted huge interest in the field of nanomedicines for their ability to overcome some physiological barriers and their potential to deliver an active molecule to a specific target without causing damage to healthy tissues. The principal objective of this review is to summarize the present knowledge on LBNC decoration used for biomedical applications, with an emphasis on the ligands used, the functionalization approaches, and the purification methods after ligand corona formation. The most potent experimental techniques for the LBNC surface characterization are described. The potential of promising methods such as nuclear magnetic resonance spectroscopy and isothermal titration calorimetry to characterize ligand surface corona is also outlined.
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| http://dx.doi.org/10.1021/acs.molpharmaceut.0c00857 | DOI Listing |
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