AI Article Synopsis
- * Salivary samples were analyzed using 16S rRNA gene sequencing, revealing that HNC patients had a higher abundance of certain oral microbes, which served as effective biomarkers with an 81% classification accuracy.
- * Combining these microbial findings with symptoms, particularly voice or speech difficulties, improved prediction accuracy to 92.5%, suggesting that salivary profiles and symptoms could aid in HNC screening.
Article Abstract
This study explored the association between oral microbes and head and neck cancer (HNC) as well as symptoms related to patients with HNC before surgical treatment. Fifty-six patients with HNC and 64 matched healthy controls were recruited from West China hospital in Southwest China. The demographic, clinical, and symptom data were collected. Salivary samples were collected to determine the microbial characteristics using 16S rRNA gene sequencing. Patients with HNC presented increased abundances. The oral microbial markers as (area under the curve=0.81) achieved a high classification power between the HNC patients and healthy controls. Moreover, using in conjunction with symptom of voice/speech difficulty achieved an overall predicting accuracy of 92.5% comparing with using alone (79.2% accuracy) in distinguishing the HNC patients from healthy controls. Salivary microbial profiles and HNC symptoms may be potential biomarkers for HNC screening.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685052 | PMC |
| http://dx.doi.org/10.3389/fcimb.2020.514943 | DOI Listing |
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