Ethnopharmacological Relevance: Since drugs currently used to manage pain and inflammatory conditions present several side effects, the investigation of new anti-inflammatory and antinociceptive agents from folk-medicine plants is an important approach. Costus spiralis (Costaceae) has been used in Brazilian medicinal teas to treat urinary infection, cough, inflammation, arthritis, among others.
Aim Of The Study: The current study focused on investigating anti-inflammatory and antinociceptive effects of fractions from C. spiralis leaves using animal models.
Materials And Methods: Adults Swiss mice were used in the following experimental models: acetic acid-induced abdominal writhing, formalin-induced nociception, hot plate, zymosan-induced peritonitis, and arthritis induced by complete Freund's adjuvant.
Results: The presence of steroids was confirmed in all fractions. Flavonoids, condensed tannins and saponins were observed in EFL. In methanolic fraction leaves (MFL), the presence of flavonoids and pentacyclic triterpenoids was confirmed. Orally administered leaf fractions significantly reduced abdominal writhing. Fractions were ineffective in the neurogenic stage of the formalin test, but in the inflammatory stage, ethyl acetate fraction levaes (AcFL), ethanolic fraction leaves (EFL), and MFL significantly reduced paw licking time by 69.6 ± 11.9%, 58.2 ± 9.4%, and 79.6 ± 8.3%, respectively. In the hot plate test, the reaction latency was similar for treated animals and controls. However, in the peritonitis test, cell migration was significantly reduced in animals treated with chloroform fractions leaves ClFL (61.8 ± 11.4%), AcFL (58.7 ± 8.3%), EFL (39.2 ± 5.0%), and MFL (64.8 ± 4.4%). This was similar to the result observed in the chronic inflammation model, this time only the chloroform fraction was able to reduce paw edema.
Conclusion: Our results show that leaf fractions of Costus spiralis are capable of modulating peripheral nociceptive and inflammatory responses without effects on central nervous system being potential substrates for phytochemical purification, structural and mechanistic studies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jep.2020.113607 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Unconventional Edible Plants of the Amazon: Bioactive Compounds, Health Benefits, Challenges, and Future Trends.
Foods
September 2024
Laboratory of Bioflavours and Bioactive Compounds, Department of Food Science, Faculty of Food Engineering, University of Campinas, Campinas 13083-862, SP, Brazil.
The pursuit of an improved quality of life is a major trend in the food market. This is driving the reformulation of the industry's product portfolio, with the aim of providing nourishment while also contributing to beneficial health metabolic processes. In this context, the use of local biodiversity and the recovery of the traditional knowledge associated with the consumption of vegetables that grow spontaneously in nature emerge as more sustainable and nutritionally adequate concepts.
View Article and Find Full Text PDFImpact of against foodborne parasite experimental infections induced variation in DNA damage, oxidative stress and PCNA expression in rat skeletal muscles.
Toxicol Res (Camb)
April 2024
Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt.
Trichinellosis is a parasite zoonosis that is spread through ingesting raw or undercooked meat that contains the Trichinella spiralis () infective larvae. It has three clinical phases: intestinal, migratory, and muscular. Kuth root, also known as Costus (Saussurea lappa) roots, is used in many traditional medical systems all over the world to treat a variety of illnesses, such as dyspepsia, diarrhoea, vomiting, and inflammation.
View Article and Find Full Text PDFCostus spiralis extract restores kidney function in cisplatin-induced nephrotoxicity model: Ethnopharmacological use, chemical and toxicological investigation.
J Ethnopharmacol
December 2022
Faculdade de Farmácia, Universidade Federal de Minas Gerais, Faculdade de Farmácia, Avenida Antônio Carlos 6627, Campus Pampulha, 31.270-901, Belo Horizonte, MG, Brazil; Consórcio Acadêmico Brasileiro de Saúde Integrativa, CABSIN, Brazil. Electronic address:
Ethnopharmacological Relevance: Costus spiralis (Jacq.). Roscoe (Costaceae) is traditionally used in Brazil for the treatment of kidney diseases such as pyelonephritis, urethra inflammation, kidney stones, and inflammatory conditions.
View Article and Find Full Text PDFFirst report of costus stripe mosaic virus infecting Tradescantia spathacea plants in Brazil.
Plant Dis
March 2021
Universidade de São Paulo - ESALQ, Fitopatologia e Nematologia, Av. Padua Dias 11, Piracicaba, São Paulo, Brazil, 13418-900;
Tradescantia spathacea (family Commelinaceae) is cultivated worldwide as an ornamental (Golczyk et al., 2013) and as medicinal plant (Tan et al., 2020).
View Article and Find Full Text PDFCostus spiralis (Jacq.) Roscoe leaves fractions have potential to reduce effects of inflammatory diseases.
J Ethnopharmacol
March 2021
Universidade Federal do Ceará (UFC), Av. da Universidade, 2853, Benfica, Fortaleza, CE, Brazil. Electronic address:
Ethnopharmacological Relevance: Since drugs currently used to manage pain and inflammatory conditions present several side effects, the investigation of new anti-inflammatory and antinociceptive agents from folk-medicine plants is an important approach. Costus spiralis (Costaceae) has been used in Brazilian medicinal teas to treat urinary infection, cough, inflammation, arthritis, among others.
Aim Of The Study: The current study focused on investigating anti-inflammatory and antinociceptive effects of fractions from C.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!