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Pimobendan oral solution is bioequivalent to pimobendan chewable tablets in beagle dogs.
J Vet Intern Med
January 2025
Boehringer Ingelheim Pharma GmbH & Co., Ingelheim, Germany.
Background: Myxomatous mitral valve disease (MMVD) is frequently diagnosed in small breed dogs. Pimobendan oral solution has been developed to improve dosing accuracy in small and toy breed dogs.
Hypothesis/objectives: Demonstrate bioequivalence of pimobendan oral solution with pimobendan chewable tablets using a pharmacokinetic and a pharmacodynamic study in healthy purpose bred dogs.
Faster intervals, faster recoveries - intensified short VO running intervals are inferior to traditional long intervals in terms of time spent above 90% VO.
Front Sports Act Living
January 2025
Department of Endurance Sports, Institute for Applied Training Science, Leipzig, Germany.
Introduction: High intensity interval training for improving maximal oxygen consumption (VO) is a fundamental component of specific preparation phases for middle- and long-distance runners. In this context, short intervals are very popular in practice. The aim of the present study was to determine whether increasing the intensity of short intervals around maximal aerobic speed (vVO), compared to traditional long interval runs, leads to a greater time spent above 90% VO.
View Article and Find Full Text PDFMidterm Outcomes of Endovascular Pulmonary Artery Debanding in Children.
Catheter Cardiovasc Interv
January 2025
Department of Pediatric Cardiology, Hotel Dieu de France University Medical Center, Saint Joseph University, Beirut, Lebanon.
Background: Pulmonary artery banding (PAB) palliates pulmonary over-circulation, while endovascular debanding (ED) offers a less invasive alternative to repeat surgery.
Objectives: To evaluate our experience with ED.
Aims: Retrospective review of single-center data (2015-2023) on children with single, multiple, or "Swiss-cheese" muscular ventricular septal defects (MVSDs) undergoing ED.
A Prospective Study on Maximal Oxygen Uptake and Cardiovascular Functions in 12-Year-Old Endurance Athletes and Their Non-Endurance-Trained Peers.
Scand J Med Sci Sports
January 2025
Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.
The maximal oxygen uptake (V̇O) is typically higher in endurance-trained adolescents than in non-endurance-trained peers. However, the specific mechanisms contributing to this remain unclear, as well as the impact of training during this developmental stage. This study aims to compare V̇O and cardiovascular functions between 12-year-old endurance athletes and non-endurance-trained over a 14-month period.
View Article and Find Full Text PDFThe widely used Ucp1-Cre transgene elicits complex developmental and metabolic phenotypes.
Nat Commun
January 2025
Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Bacterial artificial chromosome transgenic models, including most Cre-recombinases, enable potent interrogation of gene function in vivo but require rigorous validation as limitations emerge. Due to its high relevance to metabolic studies, we perform comprehensive analysis of the Ucp1-Cre line which is widely used for brown fat research. Hemizygotes exhibit major brown and white fat transcriptomic dysregulation, indicating potential altered tissue function.
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