Background: Adverse childhood experiences (ACEs) are associated with severe life-long negative outcomes, including depression. Particularly in low- and middle-income countries, few studies have been conducted to assess the impact of ACEs.
Aim: To assess the influence of ACEs on depression among young adults.
Setting: Participants were students at a large university in Gaborone, Botswana.
Methods: Using a cross-sectional design, we investigated the associations between ACEs and depression in young adults in Botswana ( = 392, mean age = 22.2, ± 2.5, 53.4% female). Bivariate correlation analyses, -tests and analyses of variance (ANOVA) were performed to assess associations and compare ACEs at different levels of depression.
Results: A total of 73% ( = 287) reported one or more ACEs, whilst 15% (59) reported five or more ACEs. About 64% (38) of those who reported five or more ACEs were female respondents. Prevalence of specific ACEs ranged from 9.5% (child neglect) to 36.3% (separation and divorce). One in three respondents reported parental separation or divorce, psychological abuse and family dysfunction, whilst 19% (11% moderate and 8% severe) reported significant depressive symptoms. Adverse childhood experiences significantly predicted depression (β = 0.27, 95% confidence interval [CI]: 0.18, 0.37). Respondents at different levels of depression significantly differed on reporting ACEs ( = 11.43, < 0.001).
Conclusion: Adverse childhood experiences are highly prevalent and key determinants of depression in young adulthood. A multifaceted and cross-system intervention (e.g. schools, social work, psychological services, health services and law enforcement) is required to protect, prevent and treat survivors of childhood adversity.
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http://dx.doi.org/10.4102/sajpsychiatry.v26i0.1444 | DOI Listing |
Neurology
January 2025
The Dubowitz Neuromuscular Centre, Developmental Neurosciences Department, University College London, Great Ormond Street Institute of Child Health, United Kingdom.
Background And Objectives: Safety and efficacy of IV onasemnogene abeparvovec has been demonstrated for patients with spinal muscular atrophy (SMA) weighing <8.5 kg. SMART was the first clinical trial to evaluate onasemnogene abeparvovec for participants weighing 8.
View Article and Find Full Text PDFPediatrics
January 2025
University of Calgary, Calgary, AB, Canada.
Context: Exposure to adverse childhood experiences (ACEs) is associated with adverse impacts on subsequent generations. The extent to which caregiver ACEs are associated with their child's ACE score is unclear.
Objective: To meta-analytically examine the association between caregiver and child ACE score.
Diabet Med
January 2025
NHS Greater Glasgow and Clyde, Glasgow, UK.
Suggested mechanisms for an association between early life adversity and worse glycaemic control.
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