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Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes.
PLoS Pathog
January 2025
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America.
Tsetse flies (Glossina spp.) vector African trypanosomes that cause devastating diseases in humans and domestic animals. Within the Glossina genus, species in the Palpalis subgroup exhibit greater resistance to trypanosome infections compared to those in the Morsitans subgroup.
View Article and Find Full Text PDFDeep mutational scanning of the Trypanosoma brucei developmental regulator RBP6 reveals an essential disordered region influenced by positive residues.
Nat Commun
January 2025
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, 06536, USA.
To regain infectivity, Trypanosoma brucei, the pathogen causing Human and Animal African trypanosomiasis, undergoes a complex developmental program within the tsetse fly known as metacyclogenesis. RNA-binding protein 6 (RBP6) is a potent orchestrator of this process, however, an understanding of its functionally important domains and their mutational constraints is lacking. Here, we perform deep mutational scanning of the entire RBP6 primary structure.
View Article and Find Full Text PDFLife history traits of the target pest and transmission routes of the biocide are critical for the success of the boosted Sterile Insect Technique.
Curr Res Insect Sci
November 2024
CIRAD, UMR CBGP, F-34398 Montpellier, France.
The sterile insect technique (SIT) is an environmentally friendly pest control strategy that consists of inundative releases of mass-reared sterilized males over defined areas, where they mate with wild females, resulting in no offspring and a declining pest population. The technique has effectively managed many crop pests and vector-borne diseases worldwide. A new approach, called boosted SIT, has been proposed to gain efficiency.
View Article and Find Full Text PDFMechanisms of life cycle simplification in African trypanosomes.
Nat Commun
December 2024
Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3FL, UK.
African trypanosomes are important parasites in sub-Saharan Africa that undergo a quorum-sensing dependent development to morphologically 'stumpy forms' in mammalian hosts to favour transmission by tsetse flies. However, some trypanosome clades have simplified their lifecycle by escaping dependence on tsetse allowing an expanded geographic range, with direct transmission between hosts achieved via blood-feeding biting flies and vampire bats (Trypanosoma brucei evansi, causing 'surra') or through sexual transmission (Trypanosoma brucei equiperdum, causing 'dourine'). Concomitantly, stumpy formation is reduced and the isolates are described as monomorphic, with infections spread widely in Africa, Asia, South America and parts of Europe.
View Article and Find Full Text PDFendosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly .
bioRxiv
October 2024
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
Tsetse flies ( spp.) vector African trypanosomes that cause devastating diseases in humans and domestic animals. Within the genus, species in the Palpalis subgroup exhibit greater resistance to trypanosome infections compared to those in the subgroup.
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