We aimed to investigate the presence of the phenicol-oxazolidinone resistance gene in linezolid-resistant enterococci from food-producing animals and analyze its molecular characteristics. We collected 3941 and 5088 isolates from all provinces of South Korea from 2008 to 2018. We found linezolid resistance in 0.79% (94/3941) of and 1.22% (62/5088) of isolates. Overall, 23.1% (36/156) of the linezolid-resistant isolates had the gene, including 31 and five isolates. The -positive enterococci were mainly isolated from chicken (86.1%; 26/36). Fifteen -harboring isolates co-carried another linezolid-resistance gene, . Eight isolates had an N130K mutation in the ribosomal protein L4, while no mutations were observed in isolates. The gene was transferred into 10 enterococci by conjugation. Multi-locus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE) analysis indicated that -carrying isolates were heterogeneous. Three isolates belonged to CC17 (ST32, ST121, and ST491). To our knowledge, this is the first report on the gene in Korea. Prudent use of antimicrobials and active surveillance on antimicrobial resistance are urgently needed to reduce the risk of dissemination of the linezolid-resistant isolates in humans and animals.
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| http://dx.doi.org/10.3390/microorganisms8111839 | DOI Listing |
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