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Effects of the GABA(B) agonist baclofen on volitional swallowing in normal subjects.
Kaohsiung J Med Sci
January 2023
Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien, Taiwan.
The GABA(B) receptor agonist baclofen is known to suppress the rate of spontaneous swallowing but not pharyngeal muscle contraction. The extent to which baclofen may alter volitional swallowing is not currently known. We investigated the effects of baclofen in healthy subjects, hypothesizing that baclofen exposure would alter volume-regulation and/or piecemeal deglutition behaviors during volitional swallowing attempts.
View Article and Find Full Text PDFBaclofen Boluses Via Lumbar Puncture for Diagnosing Loss of Intrathecal Baclofen Efficacy: A Case Series.
PM R
November 2021
Division of Physical Medicine and Rehabilitation, Nova Scotia Rehabilitation Centre, Halifax, NS, Canada.
Intrathecal Therapies.
Phys Med Rehabil Clin N Am
August 2018
MossRehab, 60 Township Line Road, Elkins Park, PA 19027, USA; Department of Rehabilitation Medicine, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:
Intrathecal baclofen therapy is a well-established technique for spasticity management. This article briefly reviews the pharmacology of intrathecal baclofen as well as customary approach for utilization of this targeted drug delivery concept. Following these descriptions, four unusual presentations will be described, including the need for initial trialing, patient-directed boluses during chronic intrathecal baclofen therapy, use of medications other than baclofen for intrathecal therapy in spastic patients, and intraventricular baclofen delivery.
View Article and Find Full Text PDFBest Practices for Intrathecal Baclofen Therapy: Dosing and Long-Term Management.
Neuromodulation
August 2016
Adult Physical Medicine & Rehabilitation, MossRehab, Elkins Park, PA, USA.
Introduction: Intrathecal baclofen (ITB) therapy aims to reduce spasticity and provide functional control.
Method: An expert panel consulted on best practices.
Results: Pump fill and drug delivery can be started intraoperatively, with monitoring for at least eight hours.
Aims: Intrathecal baclofen (ITB) has proven to be an effective and safe treatment for severe spasticity. However, although ITB is used extensively, clinical decisions are based on very scarce pharmacokinetic-pharmacodynamic (PKPD) data. The aim of this study was to measure baclofen CSF concentrations and clinical effects after administration of various ITB boluses in patients with spasticity and to create a PKPD model for ITB.
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