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Single-cell and spatial sequencing identifies senescent and germinal tumor cells in adamantinomatous craniopharyngiomas.
Cell Biosci
September 2024
Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Adamantinomatous craniopharyngioma (ACP) is a clinically aggressive tumor without effective treatment method. Previous studies proposed a paracrine tumorigenesis model, in which oncogenic β-catenin induces senescence in pituitary stem cells and the senescent cells lead the formation of paracrine tumors through secretion of pro-tumorigenic factors. However, there lacks characterization on senescent cells in ACPs.
View Article and Find Full Text PDFPosterior Fossa Craniopharyngioma Arising from the Inferior Medullary Velum.
Neurol India
July 2024
Department of Neurosurgery, National Neurosciences Centre, Calcutta, West Bengal, India.
We report the case of a 63-year-old man with a midline posterior fossa tumor and peculiar imaging features where we were unsure of the nature of the lesion preoperatively. Histopathology revealed it to be a craniopharyngioma. It appeared to arise from the inferior medullary velum, a site not described before in the literature.
View Article and Find Full Text PDFComparison of MRI findings of hypothalamic-optic chiasmatic gliomas and craniopharyngiomas.
Acta Radiol
July 2024
Division of Neuroradiology, Department of Radiology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Background: Differential diagnosis of hypothalamic-optic chiasmatic gliomas (HOCGs) and craniopharyngiomas on magnetic resonance imaging (MRI) can be quite challenging.
Purpose: To compare the MRI features of HOCGs and cranipharyngiomas.
Material And Methods: Patients diagnosed with HOCG or craniopharyngioma in histopathological evaluation between 2012 and 2022 and who underwent preoperative contrast-enhanced brain MRI were included.
Primary central nervous system tumors survival in children in ten Colombian cities: a VIGICANCER report.
Front Oncol
February 2024
Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California, San Diego, San Diego, CA, United States.
Article Synopsis
- The study focuses on survival rates of children and adolescents with primary CNS tumors in Colombia, as there's a lack of data in Latin America on this critical health issue.
- A total of 879 children and 110 adolescents were included in the study, finding a 5-year overall survival rate of 54%, with the highest survival rates for lower-grade tumors.
- Factors affecting prognosis included tumor type, location, surgical resection, and the use of radiation therapy, highlighting the importance of treatment choice in survival outcomes.
Congenital Tumors-Magnetic Resonance Imaging Findings with Focus on Rare Tumors.
Cancers (Basel)
December 2023
Department of Diagnostic Imaging, Institute of Mother and Child, 01-211 Warsaw, Poland.
Article Synopsis
- Congenital tumors are rare, and a study reviewed 839 MRI scans conducted on infants up to 3 months old, revealing that 76 tumors were diagnosed prenatally and 27 postnatally.
- The most frequently identified tumors were teratomas, particularly in the sacrococcygeal area, followed by cardiac rhabdomyomas and brain tumors associated with tuberous sclerosis.
- MRI scans are vital for accurately diagnosing these tumors, which aids in managing the pregnancy, the care of the newborn, and preparing parents psychologically for the challenges ahead.*
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