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Nilotinib Induced Keratosis Pilaris in a Female with Chronic Myeloid Leukemia.
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Department of Oncology and Hematology, School of Medicine, Saint-Joseph University, Hotel Dieu de France University Hospital and Medical Center, Beirut, Lebanon.
Tyrosine kinase enzymes are an attractive target for anticancer therapies. Tyrosine kinase inhibitors (TKI) are well tolerated; somehow severe systemic side effects are rarely seen during treatment. Toxicities of skin and appendages may lead to poor compliance, psychosocial inconvenience, and drug interruption.
View Article and Find Full Text PDFNilotinib-Induced Keratosis Pilaris.
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May 2016
Division of Dermatology, Department of Medicine, National University Health Systems, Singapore, Singapore.
Nilotinib is a second-generation Bcr-Abl tyrosine kinase inhibitor (TKI) that is approved for the treatment of imatinib-resistant chronic myeloid leukaemia expressing the Bcr-Abl mutation. Cutaneous adverse drug reactions occur more frequently in patients using this medication. We present a case of nilotinib-induced keratosis pilaris that did not have accompanying symptoms of alopecia or pruritus.
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