Cell-cycle dependent redox changes result in increased protein oxidation in mitotic cells. We show that oxidative modifications of a conserved cysteine residue within Aurora A kinase (AURKA) can promote its activation during mitosis. Targeting redox-sensitive cysteine residues within AURKA may lead to the development of novel anti-cancer agents with improved clinical efficacy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670999 | PMC |
| http://dx.doi.org/10.1080/23723556.2020.1832419 | DOI Listing |
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