The physiological response to estrogen differs according to the developmental stage. We show, in the adult, estrogen-responsiveness is driven by ERK1/2 (extracellular signal-regulated kinase 1/2) whereas its downstream effector, RSK2 (p90 ribosomal S6 kinase 2), prevents continuous ERK1/2 activity through regulation of oxidative stress. Bioinformatic analysis revealed RSK2 association with breast cancer risk and oral contraceptives.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671069 | PMC |
| http://dx.doi.org/10.1080/23723556.2020.1825916 | DOI Listing |
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