We recently demonstrated that glioblastoma, the most lethal brain cancer, upregulates diacylglycerol O-acyltransferase 1 (DGAT1) to store excess fatty acids into triglycerides to prevent lipotoxicity and promote tumor growth. Targeting DGAT1 resulted in marked tumor cell death by triggering extensive oxidative stress, indicating that DGAT1 could be a promising target for cancer therapy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671038 | PMC |
| http://dx.doi.org/10.1080/23723556.2020.1805257 | DOI Listing |
Publication Analysis
Top Keywords
target cancer
8
cancer therapy
8
dgat1
4
dgat1 protects
4
protects tumor
4
tumor lipotoxicity
4
lipotoxicity emerging
4
emerging promising
4
promising metabolic
4
metabolic target
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!