We reported that RAC1 is a master regulator of cell migration and anchorage-independent growth, downstream of the oncogenic Receptor Tyrosine Kinase (RTK) MET. RAC1 growth-promoting role is guanosine triphosphatase (GTPase)- and phosphatidylinositol 3-kinase (PI3K)-independent but promotes mammalian target of rapamycin (mTOR) signaling through triggering its plasma membrane localization.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7671004 | PMC |
| http://dx.doi.org/10.1080/23723556.2020.1803029 | DOI Listing |
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