Clinicians need to consider hepatoblastoma in the differential even in school-aged children or adolescents presenting with multiple liver tumors.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669406PMC
http://dx.doi.org/10.1002/ccr3.3138DOI Listing

Publication Analysis

Top Keywords

hepatoblastoma multiple
4
multiple tumors
4
tumors school-aged
4
school-aged child
4
child clinicians
4
clinicians consider
4
consider hepatoblastoma
4
hepatoblastoma differential
4
differential school-aged
4
school-aged children
4

Similar Publications

Most malignant hepatocellular tumors in children are classified as either hepatoblastoma (HB) or hepatocellular carcinoma (HCC), but some tumors demonstrate features of both HB and HCC . These tumors have been recognized under a provisional diagnostic category by the World Health Organization and are distinguished from HB and HCC by a combination of histological, immunohistochemical, and molecular features . Their outcomes and cellular composition remain an open question .

View Article and Find Full Text PDF

Persistent response to combination therapy of pemigatinib and chemotherapy in a child of combined hepatocellular-cholangiocarcinoma with FGFR2 fusion.

Mol Cancer

December 2024

Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Ministry of Education, Sichuan University, Chengdu, 610041, Sichuan, P.R. China.

Combined hepatocellular-cholangiocarcinoma (cHCC-CCA), an extremely rare and underinvestigated subtype of primary liver cancer in children, generally has a poor prognosis and greater aggressiveness. Histological diagnosis of cHCC-CCA is difficult because of its diverse components, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). cHCC-CCA shares some genetic alterations with HCC and CCA.

View Article and Find Full Text PDF
Article Synopsis
  • A 5-year-old boy diagnosed with hepatoblastoma had severe vascular involvement, making traditional tumor resection impossible, leading to treatment via liver transplantation.
  • After chemotherapy significantly lowered his alpha-fetoprotein levels, the boy underwent a complex transplant procedure due to extensive portal vein thrombosis and vascular transformation.
  • Post-surgery, the liver function improved significantly, indicated by reduced liver enzymes and satisfactory blood flow, despite the initial challenges of vascular abnormalities.
View Article and Find Full Text PDF

Cancer, a multifactorial pathological condition, is primarily caused due to mutations in multiple genes. Hepatocellular carcinoma (HCC) is a form of primary liver cancer that is often diagnosed at the advanced stage. Current treatment strategies for advanced HCC involve systemic therapies which are often hindered due to the emergence of resistance and toxicity.

View Article and Find Full Text PDF

[Mechanism of ganoderic acid X in treating hepatoblastoma based on proteomics].

Zhongguo Zhong Yao Za Zhi

August 2024

School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine Hefei 230012, China Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College Bengbu 233030, China.

This research explored the mechanism of ganoderic acid X(GAX) on human hepatocellular carcinoma cell models(HepG2, HuH6) and nonobese diabetic-severe combined immune deficient(NOD-SCID) mouse subcutaneous tumor models using proteomics, aiming to provide a basis for the clinical application of GAX. CCK-8 assay was employed to evaluate the effect of GAX on the viability of HepG2 and HuH6 cells. EdU assay was used to assess the effect of GAX on cell proliferation.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!