Objective: Pre-pregnancy or first trimester biomarkers predicting preterm delivery are lacking. The purpose of this study was to determine whether maternal H-antigen (secretor status) is a potential biomarker for preterm delivery.
Methods: This cohort study examined maternal saliva samples and birth data gathered by the National Children's Study Vanguard pilot phase (2009-2014) and included 300 women who were ≥18 years old and provided birth data and saliva samples. The maternal secretor status phenotype was determined by quantifying H-antigen in saliva using enzyme-linked immunoassay. Mothers were stratified by secretor status and multivariable analysis estimated adjusted associations with preterm delivery.
Results: Maternal lack of H-antigen production was an independent risk factor for preterm delivery after adjusting for known confounders (aOR 4.53; 95% CI: 1.74, 11.81; P = 0.002).
Conclusions: Maternal H-antigen may be a biomarker identifying women at-risk for preterm delivery. Prospective cohort studies validating these findings are needed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41372-020-00870-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Human Milk Oligosaccharides: Decoding Their Structural Variability, Health Benefits, and the Evolution of Infant Nutrition.
Nutrients
December 2024
Department of Molecular Biology and Genetics, Çanakkale Onsekiz Mart University, Çanakkale 17100, Türkiye.
Human milk oligosaccharides (HMOs), the third most abundant solid component in human milk, vary significantly among women due to factors such as secretor status, race, geography, season, maternal nutrition and weight, gestational age, and delivery method. In recent studies, HMOs have been shown to have a variety of functional roles in the development of infants. Because HMOs are not digested by infants, they act as metabolic substrates for certain bacteria, helping to establish the infant's gut microbiota.
View Article and Find Full Text PDFSeeding and feeding milestones: the role of human milk microbes and oligosaccharides in the temporal development of infant gut microbiota.
Gut Microbiome (Camb)
May 2024
Laboratory of Microbiology, Wageningen University & Research, Wageningen, The Netherlands.
Breastfeeding represents a strong selective factor for shaping the infant gut microbiota. Besides providing nutritional requirements for the infant, human milk is a key source of oligosaccharides, human milk oligosaccharides (HMOs), and diverse microbes in early life. This study aimed to evaluate the influence of human milk microbiota and oligosaccharides on the composition of infant faecal microbiota at one, three, and nine months postpartum.
View Article and Find Full Text PDFAssociations between ABO, FUT2 and chronic pancreatitis: A comprehensive meta-analysis of multiple cohorts and public biobanks.
Pancreatology
December 2024
Department of Gastroenterology, National Clinical Research Center for Digestive Diseases, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. Electronic address:
Objectives: Associations of ABO blood group specifying transferases A/B (ABO) and fucosyltransferase 2 (FUT2) with CP remain inconclusive. We aimed to comprehensively investigate the associations by Chinese sequencing cohorts and external cohorts.
Methods: First, we analyzed the distributions of ABO blood groups and FUT2 status, along with lead single nucleotide polymorphisms (SNPs) at ABO (rs8176693 C/T) and FUT2 (rs632111 A/G) gene loci in Chinese low-coverage whole-genome sequencing discovery cohort.
Prevalence of ABH(O) Blood Group Secretors Among Indigenous Population of Shillong: A Cross-Sectional Study.
Cureus
November 2024
Forensic Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, IND.
Article Synopsis
- ABH antigens on red blood cells determine blood types (A, B, AB, O) and are also present in various body fluids; individuals with these antigens in their fluids are known as secretors.
- A study in Shillong, India, assessed salivary secretor status in 250 healthy adults, revealing a 57.2% prevalence, with notable trends linked to age, sex, tribe, and blood groups.
- Findings highlight the forensic potential of saliva in identifying blood groups, which can assist in legal matters related to paternity, immigration, and disaster victim identification, as it can be more readily available than blood samples.
Analysis of twelve human milk oligosaccharides over fifteen months post-partum in human milk from Chinese mothers.
Heliyon
October 2024
Nutrition Research Institute, Junlebao Dairy Groups Co. Ltd, No.36 Shitong Road, Luquan, Shijiazhuang, Hebei, China.
Human milk Oligosaccharides (HMOs) are a major component in human milk and recognized to play an important role in modulating gut microbiota, intestinal cell response, and the development of the brain and immune system. While HMOs levels from Chinese mothers across different regions of China have been reported, data from Hebei are lacking. Twelve HMOs were measured from a cross-section of Hebei Han mothers over a 15-month lactation period.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!