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Peripheral Blood Eosinophilia Is Associated with Poor Outcome Post-Lung Transplantation. | LitMetric

AI Article Synopsis

  • Eosinophils, a type of white blood cell, are linked to poor outcomes in lung transplantation (LTx), particularly when found in higher levels in patients' blood.
  • A study analyzed LTx patients from 2011-2016 and found that those with elevated blood eosinophils (≥8%) had significantly worse graft survival and chronic lung allograft dysfunction (CLAD)-free survival compared to those with lower levels.
  • The results indicate that LTx recipients with high blood eosinophil counts also had a higher incidence of respiratory acute rejection (RAS), suggesting the need for more research to better understand this relationship.

Article Abstract

Eosinophils play a role in many chronic lung diseases. In lung transplantation (LTx), increased eosinophils in bronchoalveolar lavage (BAL) was associated with worse outcomes. However, the effect of peripheral blood eosinophilia after LTx has not been investigated thoroughly. A retrospective study was performed including all LTx patients between 2011-2016. Chronic lung allograft dysfunction (CLAD)-free and graft survival were compared between patients with high and low blood eosinophils using an 8% threshold ever during follow-up. A total of 102 patients (27.1%) had high blood eosinophils (≥8%) (45 before CLAD and 17 after, 40 had no CLAD) and 274 (72.9%) had low eosinophils (<8%). Patients with high blood eosinophils demonstrated worse graft survival ( = 0.0001) and CLAD-free survival ( = 0.003) compared to low eosinophils. Patients with both high blood and high BAL (≥2%) eosinophils ever during follow-up had the worst outcomes. Within the high blood eosinophil group, 23.5% had RAS compared to 3% in the group with low eosinophils ( < 0.0001). After multivariate analysis, the association between high blood eosinophils and graft and CLAD-free survival remained significant ( = 0.036, = 0.013) independent of high BAL eosinophils and infection at peak blood eosinophilia, among others. LTx recipients with ever ≥8% blood eosinophils demonstrate inferior graft and CLAD-free survival, specifically RAS, which requires further prospective research.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699939PMC
http://dx.doi.org/10.3390/cells9112516DOI Listing

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