Cancer stem cells (CSCs) are a class of pluripotent cells that have been observed in most types of cancers. Evolving evidence suggests that CSCs, has the ability to self-renew and initiate tumors, may be responsible for promoting therapeutic resistance, tumor recurrence and metastasis. Tumor heterogeneity is originating from CSCs and its progenitors are recognized as major difficulty in efficaciously treating cancer patients. Therefore, understanding the biological mechanisms by which CSCs survive chemo- and-radiation therapy has the potential to identify new therapeutic strategies in the future. In this review, we summarized recent advances in CSC biology and their environment, and discuss about the potential therapies to prevent therapeutic resistance.
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| http://dx.doi.org/10.3390/genes11111372 | DOI Listing |
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Exosomes derived from umbilical cord mesenchymal stem cells promote healing of complex perianal fistulas in rats.
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View Article and Find Full Text PDFConcentrated autologous bone marrow injection in the surgical treatment of scaphoid non-union.
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