AI Article Synopsis
- Zinc is a crucial nutrient necessary for all living organisms, but it can be toxic in high amounts, requiring careful regulation.
- The immune system employs mechanisms like chelators and membrane transporters to control zinc levels when facing pathogens such as fungi.
- This review focuses on detailing the strategies pathogenic fungi use, backed by experimental data, to regulate and maintain their zinc levels despite these immune challenges.
Article Abstract
Zinc is an essential nutrient for all living organisms. However, firm regulation must be maintained since micronutrients also can be toxic in high concentrations. This notion is reinforced when we look at mechanisms deployed by our immune system, such as the use of chelators or membrane transporters that capture zinc, when threatened with pathogens, like fungi. Pathogenic fungi, on the other hand, also make use of a variety of transporters and specialized zinc captors to survive these changes. In this review, we sought to explain the mechanisms, grounded in experimental analysis and described to date, utilized by pathogenic fungi to maintain optimal zinc levels.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711662 | PMC |
| http://dx.doi.org/10.3390/jof6040305 | DOI Listing |
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