-C-H bond functionalization of tertiary phosphines was developed using [Ru(-cymene)Cl] as a catalyst. Desired product structures were confirmed by single-crystal X-ray diffraction. Mechanistic experiments indicated that -C-H bond functionalization was a radical reaction and that a hexagonal ruthenacycle complex was a crucial intermediate in the process. Therefore, this study provides a novel method for the late-stage -position modification of biphenyl monophosphine ligands.
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| http://dx.doi.org/10.1021/acs.orglett.0c03377 | DOI Listing |
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