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Expansion of Gamma-Butyrolactone Signaling Molecule Biosynthesis to Phosphotriester Natural Products. | LitMetric

Expansion of Gamma-Butyrolactone Signaling Molecule Biosynthesis to Phosphotriester Natural Products.

ACS Chem Biol

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.

Published: December 2020

AI Article Synopsis

  • Bacterial hormones, like gamma-butyrolactone A-factor, are crucial for regulating various physiological processes, including specialized metabolism, and exhibit species-specific differences in their structures.
  • Salinipostins, a unique type of gamma-butyrolactone with antimalarial properties, were recently discovered in marine actinomycete, prompting research into their biosynthetic origins.
  • The study identified a 9-gene operon responsible for producing salinipostins and similar A-factor-like compounds, indicating that this operon is widely found in various actinomycete species, highlighting its importance in bacterial metabolism.

Article Abstract

Bacterial hormones, such as the iconic gamma-butyrolactone A-factor, are essential signaling molecules that regulate diverse physiological processes, including specialized metabolism. These low molecular weight compounds are common in species and display species-specific structural differences. Recently, unusual gamma-butyrolactone natural products called salinipostins were isolated from the marine actinomycete genus based on their antimalarial properties. As the salinipostins possess a rare phosphotriester motif of unknown biosynthetic origin, we set out to explore its construction by the widely conserved 9-gene operon in species. We show through a series of and studies that the gene cluster dually encodes the salinipostins and newly identified natural A-factor-like gamma-butyrolactones (Sal-GBLs). Remarkably, homologous biosynthetic gene clusters are widely distributed among many actinomycete genera, including , suggesting the significance of this operon in bacteria.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217639PMC
http://dx.doi.org/10.1021/acschembio.0c00824DOI Listing

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