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Parabrachial CGRP neurons modulate active defensive behavior under a naturalistic threat.
Elife
January 2025
School of Psychology, Korea University, Seoul, Republic of Korea.
Recent studies suggest that calcitonin gene-related peptide (CGRP) neurons in the parabrachial nucleus (PBN) represent aversive information and signal a general alarm to the forebrain. If CGRP neurons serve as a true general alarm, their activation would modulate both passive nad active defensive behaviors depending on the magnitude and context of the threat. However, most prior research has focused on the role of CGRP neurons in passive freezing responses, with limited exploration of their involvement in active defensive behaviors.
View Article and Find Full Text PDFAn optimized LSTM-based deep learning model for anomaly network intrusion detection.
Sci Rep
January 2025
Department of Electrical and Electronics Engineering, Manipal Institute of Technology Bengaluru, Manipal Academy of Higher Education, Manipal, India.
The increasing prevalence of network connections is driving a continuous surge in the requirement for network security and safeguarding against cyberattacks. This has triggered the need to develop and implement intrusion detection systems (IDS), one of the key components of network perimeter aimed at thwarting and alleviating the issues presented by network invaders. Over time, intrusion detection systems have been instrumental in identifying network breaches and deviations.
View Article and Find Full Text PDF[Clinical application and technical operation specification of dual plasma molecular adsorption system].
Zhonghua Gan Zang Bing Za Zhi
December 2024
The standard clinical application and operational specifications of the double plasma molecular adsorption system are summarized into eleven parts, including the treatment principles, indications and timing selection, treatment plan formulation principles, establishment and maintenance of vascular access, anti-coagulation strategy selection, instrument alarms and handling, and the efficacy evaluation indicators in the treatment of severe liver disease.
View Article and Find Full Text PDFTransfusion-transmitted bacterial infection risk due to the proliferation of psychrotrophic bacterial species in RBCs and their difficulty in detection.
Transfusion
January 2025
Japanese Red Cross Society, Central Blood Institute, Tokyo, Japan.
Background: Reports of cases of bacterial infection due to transfusion of red blood cell (RBC) components (RBC-TTBI) are relatively rare. Hence, the possibility of undetectable bacterial contamination in RBCs, especially by psychrotrophic bacteria, must be clarified.
Study Design And Methods: We assessed nine psychrotrophic bacterial species, including those implicated in bacteremia or RBC-TTBIs.
Continuous vital sign monitoring of patients recovering from surgery on general wards: a narrative review.
Br J Anaesth
January 2025
Perioperative Outcomes and Informatics Collaborative, Winston-Salem, NC, USA; Outcomes Research Consortium, Houston, TX, USA; Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Most postoperative deaths occur on general wards, often linked to complications associated with untreated changes in vital signs. Monitoring in these units is typically intermittent checks each shift or maximally every 4-6 h, which misses prolonged periods of subtle changes in physiology that can herald a critical downstream event. Continuous monitoring of vital signs is therefore intuitively necessary for patient safety.
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