Transepithelial photorefractive keratectomy (tPRK) promotes faster re-epithelialization which in turn can reduce the risk of infectious keratitis in the postoperative period. We present a case of a 22-year-old man with infectious keratitis in his left eye 8 days after an uneventful bilateral tPRK. A 2 mm × 5 mm anterior stromal area of corneal infiltration with a same sized overlying epithelial defect was noted at the time of presentation. His uncorrected distance visual acuity was 20/63 in his left eye. Corneal scrapings showed Bordetella bronchiseptica. The infection responded to intensive treatment with topical levofloxacin 0.5% eye drops. The final visual acuity was 20/20 in the left eye.
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http://dx.doi.org/10.4103/ijo.IJO_1730_20 | DOI Listing |
Curr Ther Res Clin Exp
December 2024
Department of Critical Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.
Background: Immunosuppressive agents like cyclosporine have proven effective in some pediatric cases, although there are limited case reports considering potential risks such as secondary infections.
Objective: This study investigated the safety and efficacy of Cyclosporine A in children who did not respond to high-dose corticosteroids combined with intravenous immunoglobulin (IVIG).
Methods: We reported four pediatric patients diagnosed with toxic epidermal necrolysis (TEN) received treatment at our institution.
Ophthalmol Sci
November 2024
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon.
Purpose: The diagnosis of fungal keratitis using potassium hydroxide (KOH) smears of corneal scrapings enables initiation of the correct antimicrobial therapy at the point-of-care but requires time-consuming manual examination and expertise. This study evaluates the efficacy of a deep learning framework, dual stream multiple instance learning (DSMIL), in automating the analysis of whole slide imaging (WSI) of KOH smears for rapid and accurate detection of fungal infections.
Design: Retrospective observational study.
Med Mycol Case Rep
March 2025
Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
A 42-year-old woman was referred to an emergency department. She had an unresponsive corneal ulcer that was initially diagnosed as virus keratitis. Later, the microbiological studies revealed fungal keratitis.
View Article and Find Full Text PDFClin Ophthalmol
January 2025
Center of Excellence for Cornea and Stem Cell Transplantation, Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Purpose: To develop a comprehensively deep learning algorithm to differentiate between bacterial keratitis, fungal keratitis, non-infectious corneal lesions, and normal corneas.
Methods: This retrospective study collected slit-lamp photos of patients with bacterial keratitis, fungal keratitis, non-infectious corneal lesions, and normal cornea. Causative organisms of infectious keratitis were identified by either positive culture or clinical response to single treatment.
J Clin Med
December 2024
Department of Ophthalmology, Medical University of Warsaw, Sierakowskiego 13, 01-756 Warsaw, Poland.
To evaluate visual acuity improvement and identify contributing factors in patients with severe keratitis affecting both virgin and transplanted corneas, treated at a hospital. A retrospective analysis was conducted on 497 patients with unilateral corneal ulcers treated at a tertiary referral center between 2008 and 2023. Data included distance (BCVA) and near best-corrected visual acuity at initial presentation and at discharge, treatments before hospital admission, demographic details, risk factors, clinical signs and symptoms, ancillary test results, and management strategies.
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