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Genetic Conservation and Diversity of SARS-CoV-2 Envelope Gene Across Variants of Concern.
J Med Virol
January 2025
Department of Microbiology, Howard University College of Medicine, Washington, District of Columbia, USA.
SARS-CoV-2 Envelope (E) protein is critical in viral assembly, release, and virulence. E gene was considered highly conserved and evolving slowly. Pan-sarbecoviruses-conserved regions in the E gene have been used as targets for various RT-PCR assays to detect SARS-CoV-2.
View Article and Find Full Text PDFEtiologies and Outcomes Following Duodenal Perforation in Acute Peritonitis: A Systematic Review.
Cureus
November 2024
Community and Family Medicine, All India Institute of Medical Sciences, Gorakhpur, IND.
Duodenal perforation often presents as an acute onset of abdominal pain and potential complications such as systemic infection, multiple organ system failure, and even death. It can result from various causes, including peptic ulcer disease (PUD), trauma, malignancies, and infections. Prompt diagnosis and timely intervention are critical for better outcomes, though mortality can be high, particularly in delayed cases.
View Article and Find Full Text PDFAdvanced Management of Complex Transplant Lithiasis: Low Lithotomy and Boot Stirrups Technique.
Am J Case Rep
January 2025
Department of Urology, The University of Hong Kong - Shenzhen Hospital, Shenzhen, Guangdong, China.
BACKGROUND Transplant lithiasis may be rare but poses significant risk to the renal graft function of the recipient. Immediate management is necessitated upon first detection, to prevent further complications. CASE REPORT We report 2 cases of transplant lithiasis that were not treated immediately upon first detection.
View Article and Find Full Text PDFImplant survival at four years for hemiarthroplasty and total shoulder arthroplasty in the treatment of atraumatic avascular necrosis of the humeral head.
Bone Joint J
January 2025
Department of Orthopaedics, Medical Spectrum Twente, Enschede, Netherlands.
Aims: Hemiarthroplasty (HA) and total shoulder arthroplasty (TSA) are often the preferred forms of treatment for patients with atraumatic avascular necrosis of the humeral head when conservative treatment fails. Little has been reported about the survival of HA and TSA for this indication. The aim of this study was to investigate the differences in revision rates between HA and TSA in these patients, to determine whether one of these implants has a superior survival and may be a better choice in the treatment of this condition.
View Article and Find Full Text PDFPredicting kidney graft function and failure among kidney transplant recipients.
BMC Med Res Methodol
December 2024
Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Background: Graft loss is a major health concern for kidney transplant (KTx) recipients. It is of clinical interest to develop a prognostic model for both graft function, quantified by estimated glomerular filtration rate (eGFR), and the risk of graft failure. Additionally, the model should be dynamic in the sense that it adapts to accumulating longitudinal information, including time-varying at-risk population, predictor-outcome association, and clinical history.
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