Introduction: The current COVID-19 pandemic reveals the dangerousness of infectious diseases and the threats we face. Often however, effective vaccinations are carried out insufficiently. In March 2020, the German measles protection law was introduced to raise the level of population (herd) immunity to over 95 %.
Methods: An anonymous online survey was conducted among the population on the Measles Protection Act with self-declarations on measles vaccination/illness of participants and their children and evaluation of various sanctions.
Results: 1,594 adults participated. 19.3 % were affected by the law. Of these, only 77.5 % were immune to measles, 14.0 % wanted to be fully vaccinated when the law came into force, which would lead to 91.5 % immunity. Assuming that participants with unclear vaccination status or measles disease are immune, an immunity of>95 % can be achieved. 86.4 % of the children (aged 2 to 17 years) had developed immunity. Parents' willingness to have their children vaccinated because of the sanctions provided for in the Measles Protection Act was only 0.8 %.
Conclusion: The level of immunity to measles in adults and children was under 95 % in our study. The sanctions of the Measles Protection Act are a greater incentive for adults to undergo measles vaccination than for parents. Strategies to increase immunity with the target group of parents should continue to be pursued.
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http://dx.doi.org/10.1016/j.zefq.2020.10.009 | DOI Listing |
J Virol
January 2025
Microbiology and Immunology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA.
Measles virus (MeV) is a highly contagious respiratory virus transmitted via aerosols. To understand how MeV exits the airways of an infected host, we use unpassaged primary cultures of human airway epithelial cells (HAE). MeV typically remains cell-associated in HAE and forms foci of infection, termed infectious centers, by directly spreading cell-to-cell.
View Article and Find Full Text PDFMikrobiyol Bul
October 2024
Dokuz Eylül University Faculty of Medicine, Department of Medical Microbiology, İzmir, Türkiye.
Measles, rubella, mumps and chickenpox infections are among the childhood diseases that can be prevented by vaccination. Healthcare workers are at greater risk of diseases transmitted through contact with patients' respiratory secretions, infected blood and body fluids. Students studying in the field of health are at the risk of encountering infectious diseases as much as healthcare personnel during their internship and practice experience in healthcare institutions during their education.
View Article and Find Full Text PDFJ Med Virol
December 2024
Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Despite the availability of a highly efficacious vaccine, a global resurgence of measles infections has occurred, largely due to decreased vaccination coverage and waning immunity following the two-dose vaccination schedule. This study aims to assess the cellular immune response in individuals who did not respond to the two-dose MMR vaccine and evaluate the efficacy and durability of immune responses after booster doses. An observational study was conducted involving 24 individuals who were seronegative for measles years after completing the two-dose MMR vaccine schedule.
View Article and Find Full Text PDFHum Vaccin Immunother
December 2024
Interactions hôte-pathogène, Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France.
Measles live attenuated vaccine (MV) induces strong humoral and cellular systemic memory responses allowing the successful control of measles since decades. MV has also been adapted into a promising vaccine platform with several vaccine candidates in clinical development. To understand and document the tissue-scaled memory response induced by MV, we explored the specific induction and persistence of resident memory T cells (Trm) in the lungs and the liver, two critical targeted tissues for vaccine development against several diseases.
View Article and Find Full Text PDFJ Infect Dev Ctries
November 2024
Emeritus, Department of Public Health, Istanbul Medeniyet University Faculty of Medicine, Istanbul, Turkey.
Introduction: Intravenous immunoglobulin (IVIG) is an alternative for post-exposure prophylaxis if a vaccine is contraindicated and intramuscular immunoglobulin is unavailable. We retrospectively examined the effect of IVIG administration time on measles development in measles-contact infants younger than 6 months of age.
Methodology: Contact tracing of measles cases was performed by the Istanbul Public Health Directorate (IPHD) between August 24, 2012, and June 16, 2013.
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