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Alliance A022104/NRG-GI010: The Janus Rectal Cancer Trial: a randomized phase II/III trial testing the efficacy of triplet versus doublet chemotherapy regarding clinical complete response and disease-free survival in patients with locally advanced rectal cancer.
BMC Cancer
July 2024
Memorial Sloan Kettering Cancer Center, 1275 York Avenue, SR-201, New York, NY, 10065, USA.
Article Synopsis
- * The design of a new NCI-sponsored randomized trial aims to determine the best chemotherapy regimen for patients who achieve a clinical complete response (cCR) after TNT, potentially allowing for a "watch and wait" strategy instead of immediate surgery.
- * The trial will enroll up to 760 patients with specific LARC criteria and will evaluate the effectiveness of long-course chemoradiation followed by different consolidation chemotherapy regimens, with patient outcomes being monitored over time.
Motion capture device reveals a quick learning curve in vascular anastomosis training.
Surg Today
March 2024
Department of Vascular Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Purpose: Surgical procedures are often evaluated subjectively, and an objective evaluation has been considered difficult to make and rarely reported, especially in open surgery, where the range of motion is wide. This study evaluated the effectiveness of surgical suturing training as an educational tool using the Leap Motion Controller (LMC), which can capture hand movements and reproduce them as data comprising parametric elements.
Methods: We developed an off-the-job training system (Off-JT) in our department, mainly using prosthetic grafts and various anastomotic methodologies with graded difficulty levels.
Beyond the anastomosis - look before you leap into microsurgery!
Br J Oral Maxillofac Surg
February 2021
Department of Oral and Maxillofacial Surgery, Queen Victoria Hospital NHS Foundation Trust, Holtye Road, East Grinstead, RH19 3DZ. Electronic address:
Early (6 months) results of a pilot prospective study to investigate the efficacy and safety of sirolimus coated balloon angioplasty for dysfunctional arterio-venous fistulas: MAgicTouch Intervention Leap for Dialysis Access (MATILDA) Trial.
PLoS One
December 2020
Department of Vascular Surgery, Singapore General Hospital, Singapore, Singapore.
Background: The aim of this pilot study was to evaluate the safety and efficacy of the MagicTouch™ sirolimus-coated balloon (SCB) catheter (Concept Medical Inc., Tampa, FL, US) on improving the patency of failing arterio-venous fistulas (AVF) with de novo and recurrent stenoses. MATILDA reports early outcomes at 3- and 6 months post intervention.
View Article and Find Full Text PDFThink before you leap: cutaneous hypersensitivity to polytetrafluoroethylene arteriovenous graft masquerading as infection.
BMJ Case Rep
September 2019
Medicine/Nephrology, University of Florida, Gainesville, Florida, USA.
Polytetrafluoroethylene (PTFE) graft is a synthetic graft commonly used in chronic haemodialysis patients. Expected complications of synthetic grafts include infection, thrombosis, oedema and pain. PTFE is a non-textile graft that is chemically inert, electronegative and hydrophobic.
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