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Impact of general practitioner appointment frequency on disease management in type 2 diabetes mellitus patients.
Prim Care Diabetes
January 2025
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain; Department of Medicine. University of Oviedo, Oviedo, Spain; Servicio de Endocrinología y Nutrición, Hospital Universitario Central de Asturias, Oviedo, USA.
Aims: We investigated the association between the frequency of visits to general practitioners (GPs) and the degree of disease control in patients with T2DM.
Methods: This study included patients diagnosed with T2DM who visited their GPs between 2014 and 2018. A total of 89,674 patients, accounting for 1,203,035 visits, were included.
Diagnostic Performance of the Modified Lung-RADS in a Tuberculosis-endemic Country: The Korean National Lung Cancer Screening Program.
Chest
January 2025
Division of Cancer Early Detection, National Cancer Control Institute, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang 10408, Korea. Electronic address:
Background: In 2019, Korea initiated the world's first national low-dose computed tomography (CT) lung cancer screening (LCS) program, adapting the Lung CT Screening Reporting and Data System (Lung-RADS) to counteract the high false-positive rates driven by prevalent tuberculosis.
Research Question: Does the modified Lung-RADS enhance screening specificity while maintaining sensitivity?
Study Design And Methods: This nationwide, retrospective, cohort study included high-risk current smokers aged 54 to 74 with at least 30 pack-years, participating in the national LCS program from 2019 to 2020. The modified Lung-RADS 1.
Comprehensive Extractables and Leachables Sensitization Analysis and Practical Application of a Risk-Based Approach to Sensitization Assessment for Parenteral Drug Products.
Regul Toxicol Pharmacol
January 2025
Faegre Drinker Biddle & Reath LLP, Washington, DC, USA.
The Extractables and Leachables Safety Information Exchange (ELSIE) Consortium added to the sensitization potency analysis of Parris et al. (2023) by including the Product Quality Research Institute (PQRI) extractable and leachable dataset (Johnson et al., 2024; Product Quality Research Institute, 2021).
View Article and Find Full Text PDFIntroduction: ND0612 is being investigated as a continuous, subcutaneous levodopa/carbidopa infusion, in combination with oral levodopa/carbidopa, for motor fluctuations in Parkinson's disease (PD). One-year data from the ongoing BeyoND study (NCT02726386) showed that the ND0612 regimen was safe and well tolerated and provided a sustained ≥2-h improvement in daily Good ON-time through 12 months of treatment.
Methods: We describe 3-year safety and efficacy outcomes for participants who completed 12 months of ND0612 treatment in the core study period and entered the extension phase.
Changes in structural composition of field margins and related landscape homogenization following EU accession of Poland.
Sci Rep
January 2025
Department of Botany, University of Wrocław, Kanonia 6/8, 50-328, Wrocław, Poland.
Field margins have considerable ecological significance in farming landscapes, but are subject to constant changes resulting from natural processes and anthropogenic pressures. Understanding the balance of these processes is important from an ecological and conservation perspective. We measured 20 variables related to margin composition, woody vegetation and adjacent cropland fragmentation in 70 field margins in SW Poland in 2004 and 2006 (Poland's accession to the EU), and then resurveyed in 2021 by using the same protocol.
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