AI Article Synopsis
- Cucurmosin shows potential as an effective alternative to gemcitabine for treating pancreatic cancer, exhibiting dose-dependent tumor inhibition.
- High-dose cucurmosin achieves similar therapeutic effects as gemcitabine by enhancing metabolic processes and inducing tumor cell apoptosis through specific biochemical mechanisms.
- Further research is necessary to optimize dosages and explore its efficacy in clinical settings, tailoring treatments to different stages of pancreatic cancer.
Article Abstract
Background: As the preferred drug for single chemotherapeutic application in pancreatic cancer, gemcitabine often demonstrated low sensitivity and strong chemotherapy resistance in patients. Therefore, the search for other drugs with high efficiency and low side effects has become of high importance. The aim of this study was to assess the therapeutic effects of cucurmosin on pancreatic cancer as an alternative of gemcitabine and explore its underlying biochemical mechanism.
Methods: The subcutaneous xenograft mice with pancreatic cancer were treated by high- and low-dose cucurmosin and gemcitabine, respectively. A comparative metabolomic analysis was performed on the serum samples from the different groups by 1H nuclear magnetic resonance (NMR) techniques and then subjected to univariate and multivariate statistical analysis.
Results: Cucurmosin demonstrated a dose-dependent inhibition to the pancreatic tumors. High-dose cucurmosin provided similar chemotherapeutic efficacy with gemcitabine by positively regulating pyruvate metabolism, glycolysis or gluconeogenesis, and cysteine and methionine metabolism. Inactivating GFR signaling pathway and further inducing apoptosis of tumor cells are the important mechanism of anti-tumor function of cucurmosin.
Conclusions: Cucurmosin is a promising chemotherapeutic drug for pancreatic cancer. However, the dose selection and surface modification should be optimized according to the stage of pancreatic cancer, and an expanded study in both laboratory and clinical regimes needs to be performed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667084 | PMC |
| http://dx.doi.org/10.21037/gs-20-202 | DOI Listing |
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