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http://dx.doi.org/10.1007/s40670-020-01166-x | DOI Listing |
Nat Cancer
January 2025
Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Human tumors are diverse in their natural history and response to treatment, which in part results from genetic and transcriptomic heterogeneity. In clinical practice, single-site needle biopsies are used to sample this diversity, but cancer biomarkers may be confounded by spatiogenomic heterogeneity within individual tumors. Here we investigate clonally expressed genes as a solution to the sampling bias problem by analyzing multiregion whole-exome and RNA sequencing data for 450 tumor regions from 184 patients with lung adenocarcinoma in the TRACERx study.
View Article and Find Full Text PDFCell Rep
January 2025
Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address:
Growing evidence suggests that ribosomes selectively regulate translation of specific mRNA subsets. Here, quantitative proteomics and cryoelectron microscopy demonstrate that poxvirus infection does not alter ribosomal subunit protein (RP) composition but skews 40S rotation states and displaces the 40S head domain. Genetic knockout screens employing metabolic assays and a dual-reporter virus further identified two RPs that selectively regulate non-canonical translation of late poxvirus mRNAs, which contain unusual 5' poly(A) leaders: receptor of activated C kinase 1 (RACK1) and RPLP2.
View Article and Find Full Text PDFPharmaceutics
November 2024
College of Textile Science and Engineering (International Silk Institute), Zhejiang Sci-Tech University, Hangzhou 310018, China.
Background/objectives: The use of natural colourants is gaining attention due to their biocompatibility and functional benefits. This study introduces a different approach using turmeric ( L.) dye extract combined with chitosan to significantly enhance the antibacterial and UV-shielding properties of silk.
View Article and Find Full Text PDFMaterials (Basel)
December 2024
School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China.
The presence of island grains in the initial finished sheets of grain-oriented electrical steel is inevitable in the preparation of ultra-thin strips. Owing to their distinctive shape and size effects, their deformation behavior during rolling differs from that of grain-oriented electrical steels of conventional thickness. This study focuses on the orientation evolution and deformation heterogeneity of island grains during rolling.
View Article and Find Full Text PDFSoft Matter
January 2025
Departamento de Física, Universidade Federal do Ceará, Caixa Postal 6030, 60455-760 Fortaleza, Ceará, Brazil.
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