Chemical Composition and Biological Activities of Endophytic Fungus LGT-4, Cultured in CYM Medium.

In the present study, nine compounds (-) were isolated from LGT-4 (an endophytic fungus from ) which was cultured in CYM Medium. Their structures were determined as 4-hydroxyphthalide (), Fumitremorgin C (), Ergosterol (), 3-(2-hydroxypropyl)-8-hydroxy-3,4- dihydroisocoumarin (), Cis-cyclo(-Ala--Pro) (), 6-Amino-3-(4-hydroxybenzyl)- 1,4-diazonane-2,5-dione (), Aspergillumarin B (), Deacetylisowortmin B (), and Entonaemin A () based on NMR spectral data, as well as comparing with previous literature data. This is the first report of the isolation of compounds - and - from genus. All compounds were tested for their monoamine oxidase and phosphoinositide 3-kinase (PI3Kα) inhibitory activities. Compound , showed moderate anti-monoamine oxidase activity with IC value of 35 μg/mL, 28 μg/mL, respectively. Compound showed PI3K inhibitory activity with IC value of 10.3 /mL.