The North American Hybrid Algorithm has become the standard method for percutaneous intervention for coronary chronic total occlusions. In this article, the authors discuss antegrade wire escalation as it applies to the North American Hybrid Algorithm for chronic total occlusion percutaneous coronary intervention. There is a multitude of guidewires available to operators on the market, which can quickly prove overwhelming in terms of selection, cost, and practicality. The authors simplify wires into four overall groups or families. Operators should be able to pare their toolbox down to four wires only to achieve success at antegrade wire escalation.
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