Despite significant improvement in understanding of molecular underpinnings driving glioblastoma, there is minimal improvement in overall survival of patients. This poor outcome is caused in part by traditional designs of early phase clinical trials, which focus on clinical assessments of drug toxicity and response. Window of opportunity trials overcome this shortcoming by assessing drug-induced on-target molecular alterations in post-treatment human tumor specimens. This article provides an overview of window of opportunity trials, including novel designs for incorporating biologic end points into early stage trials in context of brain tumors, and examples of successfully executed window of opportunity trials for glioblastoma.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927773 | PMC |
| http://dx.doi.org/10.1016/j.nec.2020.09.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pediatric Sleep Apnoea and Passive Smoking: A Window of Opportunity?
Open Respir Arch
November 2024
Pneumology Department, University Hospital of Saint John of Alicante, Spain.
Mapping two decades of research in rheumatology-specific journals: a topic modeling analysis with BERTopic.
Ther Adv Musculoskelet Dis
December 2024
Grupo de Patología Musculoesquelética, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos, Madrid, Spain.
Background: Rheumatology has experienced notable changes in the last decades. New drugs, including biologic agents and Janus kinase (JAK) inhibitors, have blossomed. Concepts such as window of opportunity, arthralgia suspicious for progression, or difficult-to-treat rheumatoid arthritis (RA) have appeared; and new management approaches and strategies such as treat-to-target have become popular.
View Article and Find Full Text PDFExploiting full-duplex opportunities in WLANs via a reinforcement learning-based medium access control protocol.
Sci Rep
December 2024
National University of Defense Technology, Changsha, Hunan, China.
In-band full-duplex communication has the potential to double the wireless channel capacity. However, how to efficiently transform the full-duplex gain at the physical layer into network throughput improvement is still a challenge, especially in dynamic communication environments. This paper presents a reinforcement learning-based full-duplex (RLFD) medium access control (MAC) protocol for wireless local-area networks (WLANs) with full-duplex access points.
View Article and Find Full Text PDFIndividual-, Hospital-, And Community-Level Factors Associated With Sudden Unexpected Infant Death Among Infants Born Preterm in 5 US States.
J Pediatr
December 2024
Division of Neonatology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania.
Objective: To investigate individual-, hospital-, and community-level factors associated with sudden unexpected infant death (SUID) among infants born preterm.
Study Design: The following linked dataset from 5 states (California, Michigan, Oregon, Pennsylvania, and South Carolina) from 2005 through 2020 was used: 1) infant birth and death certificates; 2) maternal and infant birth hospitalization discharge records; 3) birthing hospital data from the American Hospital Association; and 4) community-level data from the Social Vulnerability Index (SVI).) Multivariable models were used to assess the independent association between these multi-level factors and SUID, adjusting for several maternal and infant characteristics.
Excessive hypercholesterolaemia during pregnancy as a risk factor for endothelial dysfunction in pre-eclampsia.
J Physiol
December 2024
Department of Obstetrics & Gynecology, University of Alberta, Edmonton, AB, Canada.
Pregnancy induces significant changes in the maternal cardiovascular system, and insufficient vascular endothelial adaptations to pregnancy contribute to the development of pregnancy complications such as pre-eclampsia. Pre-eclampsia is not only a major cause of maternal morbidity and mortality, but also a significant risk factor for the development of later-life cardiovascular disease. However, the specific mechanisms underlying the pathophysiology of pre-eclampsia, as well as the mechanisms for an increased susceptibility to cardiovascular disease later in life, are not fully characterized.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!