Aim: To assess how blood-flow-restricted (BFR) interval-training affects the capacity of the leg muscles for pH regulation during dynamic exercise in physically trained men.
Methods: Ten men (age: 25 ± 4y; : 50 ± 5 mL∙kg ∙min ) completed a 6-wk interval-cycling intervention (INT) with one leg under BFR (BFR-leg; ~180 mmHg) and the other without BFR (CON-leg). Before and after INT, thigh net H -release (lactate-dependent, lactate-independent and sum) and blood acid/base variables were measured during knee-extensor exercise at 25% (Ex25) and 90% (Ex90) of incremental peak power output. A muscle biopsy was collected before and after Ex90 to determine pH, lactate and density of H -transport/buffering systems.
Results: After INT, net H release (BFR-leg: 15 ± 2; CON-leg: 13 ± 3; mmol·min ; Mean ± 95% CI), net lactate-independent H release (BFR-leg: 8 ± 1; CON-leg: 4 ± 1; mmol·min ) and net lactate-dependent H release (BFR-leg: 9 ± 3; CON-leg: 10 ± 3; mmol·min ) were similar between legs during Ex90 (P > .05), despite a ~142% lower muscle intracellular-to-interstitial lactate gradient in BFR-leg (-3 ± 4 vs 6 ± 6 mmol·L ; P < .05). In recovery from Ex90, net lactate-dependent H efflux decreased in BFR-leg with INT (P < .05 vs CON-leg) owing to lowered muscle lactate production (~58% vs CON-leg, P < .05). Net H gradient was not different between legs (~19%, P > .05; BFR-leg: 48 ± 30; CON-leg: 44 ± 23; mmol·L ). In BFR-leg, NHE1 density was higher than in CON-leg (~45%; P < .05) and correlated with total-net H -release (r = 0.71; P = .031) and lactate-independent H release (r = 0.74; P = .023) after INT, where arterial [ ] and standard base excess in Ex25 were higher in BFR-leg than CON-leg.
Conclusion: Compared to a training control, BFR-interval training increases the capacity for pH regulation during dynamic exercise mainly via enhancement of muscle lactate-dependent H -transport function and blood H -buffering capacity.
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We investigated the influence of short- and long-interval cycling exercise with blood flow restriction (BFR) on neuromuscular fatigue, shear stress and muscle oxygenation, potent stimuli to BFR-training adaptations. During separate sessions, eight individuals performed short- (24 × 60 s/30 s; SI) or long-interval (12 × 120 s/60 s; LI) trials on a cycle ergometer, matched for total work. One leg exercised with (BFR-leg) and the other without (CTRL-leg) BFR.
View Article and Find Full Text PDFThe effect of blood-flow-restricted interval training on lactate and H dynamics during dynamic exercise in man.
Acta Physiol (Oxf)
March 2021
Section of Integrative Physiology, Department of Nutrition, Exercise and Sports (NEXS), University of Copenhagen, Copenhagen Ø, Denmark.
Aim: To assess how blood-flow-restricted (BFR) interval-training affects the capacity of the leg muscles for pH regulation during dynamic exercise in physically trained men.
Methods: Ten men (age: 25 ± 4y; : 50 ± 5 mL∙kg ∙min ) completed a 6-wk interval-cycling intervention (INT) with one leg under BFR (BFR-leg; ~180 mmHg) and the other without BFR (CON-leg). Before and after INT, thigh net H -release (lactate-dependent, lactate-independent and sum) and blood acid/base variables were measured during knee-extensor exercise at 25% (Ex25) and 90% (Ex90) of incremental peak power output.
Training with blood flow restriction increases femoral artery diameter and thigh oxygen delivery during knee-extensor exercise in recreationally trained men.
J Physiol
June 2020
Section of Integrative Physiology. Department of Nutrition, Exercise and Sports (NEXS), University of Copenhagen, Copenhagen, Denmark.
Key Points: Endurance-type training with blood flow restriction (BFR) increases maximum oxygen uptake ( ) and exercise endurance of humans. However, the physiological mechanisms behind this phenomenon remain uncertain. In the present study, we show that BFR-interval training reduces the peripheral resistance to oxygen transport during dynamic, submaximal exercise in recreationally-trained men, mainly by increasing convective oxygen delivery to contracting muscles.
View Article and Find Full Text PDFCycling with blood flow restriction improves performance and muscle K regulation and alters the effect of anti-oxidant infusion in humans.
J Physiol
May 2019
Section of Integrative Physiology, Department of Nutrition, Exercise and Sports (NEXS), University of Copenhagen, Copenhagen, Denmark.
Article Synopsis
- Training with blood flow restriction (BFR) enhances muscle performance and potassium (K) regulation during high-intensity exercise in active men.
- BFR training leads to improved blood flow to exercising muscles and positive changes in anti-oxidant function, as shown by a higher GSH:GSSG ratio.
- Adaptations observed include fibre type-specific increases in Na⁺, K⁺-ATPase isoforms, suggesting a targeted response to intense exercise with BFR.
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