Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic mutations in normal human tissues, and here we discuss their implications for our understanding of tumorigenesis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ccell.2020.11.002 | DOI Listing |
Publication Analysis
Top Keywords
somatic mutations
8
normal somatic
4
mutations cancer
4
cancer transformation
4
transformation gene
4
gene alterations
4
alterations play
4
play prominent
4
prominent role
4
role driving
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!