We describe the clinical, serologic, and molecular findings of a new human rickettsiosis in Colombia. Antibodies against Rickettsia spp. were detected. PCR showed amplification of genes for R. parkeri strain Atlantic Rainforest. This new rickettsiosis of minor virulence could explain some of the undifferentiated acute febrile diseases in Colombia.
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http://dx.doi.org/10.3201/eid2612.200388 | DOI Listing |
J Cell Biol
March 2025
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Upon invasion into the host cell, a subset of bacterial pathogens resides exclusively in the cytosol. While previous research revealed how they reshape the plasma membrane during invasion, subvert the immune response, and hijack cytoskeletal dynamics to promote their motility, it was unclear if these pathogens also interacted with the organelles in this crowded intracellular space. Here, we examined if the obligate intracellular pathogen Rickettsia parkeri interacts with the endoplasmic reticulum (ER), a large and dynamic organelle spread throughout the cell.
View Article and Find Full Text PDFPathogens
December 2024
Centro di Referenza Nazionale per Anaplasma, Babesia Rickettsia, e Theileria (C.R.A.Ba.R.T.), Istituto Zooprofilattico Sperimentale della Sicilia "A. Mirri", 90129 Palermo, Italy.
Vector-borne diseases represent a serious threat to human and animal health, especially where environmental conditions favor pathogen-carrying vectors. Dogs serve as natural hosts for two tick-borne pathogens: , which causes canine monocytic ehrlichiosis, and spotted fever group (SFG) spp., a zoonotic threat in the Mediterranean region.
View Article and Find Full Text PDFPathogens
November 2024
ANSES, INRAE, Ecole Nationale Vétérinaire d'Alfort, UMR BIPAR, Laboratoire de Santé Animale, F-94700 Maisons-Alfort, France.
Vector-borne diseases pose significant challenges for both animal and public health worldwide [...
View Article and Find Full Text PDFSci Rep
January 2025
Department of Biochemistry, Bahauddin Zakariya University, Multan, 66000, Punjab, Pakistan.
Rocky Mountain Spotted Fever, caused by the gram-negative intracellular bacteria Rickettsia rickettsii, is a serious tick-borne infection with a fatality rate of 20-30%, if not treated. Since it is the most serious rickettsial disease in North America, modified prevention and treatment strategies are of critical importance. In order to find new therapeutic targets and create multiepitope vaccines, this study integrated subtractive proteomics with reverse vaccinology.
View Article and Find Full Text PDFActa Trop
January 2025
Professor, Department of Paediatrics, All India Institute of Medical Sciences [AIIMS], Bhubaneswar, Odisha.751019. Electronic address:
Spotted fever group Rickettsia (SFGR) infections remain largely under-investigated as causative agents of acute undifferentiated febrile illness (AUFI) in resource-limited settings. Few studies are available on the prevalence of SFGR infections in India, especially in eastern India. In a cross-sectional study conducted in 192 hospitalized adult and paediatric patients with AUFI, the frequency of SFGR using sequential PCR targeting genes encoding citrate synthase gene (gltA), 17 kDa lipoprotein precursor antigen (17kDa), outer membrane proteins A and B (omp A & omp B) was 6.
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