We comment on the recently published Martini forcefield for linear polyethylenimine (Beu et al., J. Comput. Chem., 2020, 41, 349). With supporting evidence, we demonstrate that the new coarse-graining methodology presented in that work is inconsistent with the Martini methodology and lacks important validation steps which is usually required by Martini forcefields.
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http://dx.doi.org/10.1002/jcc.26453 | DOI Listing |
Autophagy
January 2025
School of Medicine, Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany.
Intrinsically disordered regions (IDRs) are crucial to homeostatic and organellar remodeling pathways. In reticulophagy/ER-phagy, long cytosolic IDR-containing receptors (e.g.
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October 2023
Nature Cardiovascular Research, .
Nat Cardiovasc Res
December 2023
Nature Cardiovascular Research, .
Biochim Biophys Acta Proteins Proteom
July 2024
Laboratoire de Biologie et Modélisation de la Cellule, CNRS, UMR 5239, Inserm, U1293, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69364 Lyon, France; Centre Blaise Pascal de Simulation et de Modélisation Numérique, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69364 Lyon, France. Electronic address:
Genes (Basel)
February 2024
Control and Computer Engineering Department, Politecnico di Torino, 10129 Torino, Italy.
It is well known how sequencing technologies propelled cellular biology research in recent years, providing incredible insight into the basic mechanisms of cells. Single-cell RNA sequencing is at the front in this field, with single-cell ATAC sequencing supporting it and becoming more popular. In this regard, multi-modal technologies play a crucial role, allowing the possibility to simultaneously perform the mentioned sequencing modalities on the same cells.
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