All women (n = 223) scheduled for induction of labor were randomized into start with oxcytocin infusion (O) or amniotomy (A). After 4 h an assessment of the progress and prognosis was made. If the progress was not acceptable O was added to A and A to O. Oxcytocin alone showed the lowest frequency of delivered patients. The "amniotomy only" group showed the shortest duration of delivery. The frequency of complications was low but somewhat higher when the initial step was oxcytocin. Oxcytocin alone is not a good method for induction. Early evaluation of the progress and prognosis of the induction is difficult. The combination of amniotomy and oxcytocin seem to be more essential than the choice of initial step. If, however, an infusion of oxcytocin is the first proceeding, amniotomy should be added on a routine basis and without delay. Bishop score is not a conclusive measure of the readiness of uterus to go into labor. Parity may partly be the explanation but other today unknown factors are probably involved in the inducibility.
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http://dx.doi.org/10.3109/00016348709015731 | DOI Listing |
Elife
December 2024
Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.
Since the precursor frequency of naive T cells is extremely low, investigating the early steps of antigen-specific T cell activation is challenging. To overcome this detection problem, adoptive transfer of a cohort of T cells purified from T cell receptor (TCR) transgenic donors has been extensively used but is not readily available for emerging pathogens. Constructing TCR transgenic mice from T cell hybridomas is a labor-intensive and sometimes erratic process, since the best clones are selected based on antigen-induced CD69 upregulation or IL-2 production in vitro, and TCR chains are polymerase chain reaction (PCR)-cloned into expression vectors.
View Article and Find Full Text PDFInt J Gynaecol Obstet
January 2025
The Josef Buchmann Gynecology and Maternity Center, Sheba Medical Center, Tel Hashomer, Israel.
Objective: This study explores a hybrid approach to maternal-fetal care for gestational diabetes (GD), integrating virtual visits seamlessly with in-clinic assessments. We assessed the feasibility, time efficiency, patient satisfaction, and clinical outcomes to facilitate wider adoption of maternal-fetal telemedicine.
Methods: We conducted a 4-week prospective study involving 20 women with GD at ≥32 weeks of pregnancy, alternating between remote and in-clinic weekly visits.
Am J Obstet Gynecol MFM
January 2025
Department of Obstetrics and Gynecology, Galilee Medical Center, Nahariya, Israel; Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.
Background: Assessing maternal pain and satisfaction following administration of paracetamol vs. placebo prior to catheter balloon placement.
Methods: Primiparous women at term admitted for medically-indicated labor induction were randomized to receive intravenous paracetamol 1 gram in 100cc normal saline (N=71) or placebo of 100cc normal saline (N=70) prior to catheter balloon insertion.
J Hazard Mater
January 2025
College of Engineering and Technology, Southwest University, Chongqing 400716, PR China. Electronic address:
The detection of heavy metals in soil is of great scientific significance for food security and human health. However, traditional detection methods are complicated, time-consuming, and labor-intensive. Herein, we developed a novel method using Au@SiO nanoparticles (NPs) and surface microstructure combined with laser-induced breakdown spectroscopy (Au@SiO NPs-SMS-LIBS) for the rapid detection of lead (Pb), chromium (Cr), and copper (Cu) in soil samples.
View Article and Find Full Text PDFTrials
January 2025
Women's Health, Te Whatu Ora Te Toka Tumai Auckland, 2 Park Road, Grafton, Auckland, 1023, New Zealand.
Background: The approach to induction of labour differs internationally, with timing of amniotomy being controversial. Some institutions favour performing artificial rupture of membranes prior to commencement of oxytocin infusion, with the belief that the labour will progress more efficiently. In other institutions, the approach recommended is for oxytocin infusion with intact amniotic membranes until the person has reached the active phase of labour, citing risk of infection with early amniotomy.
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