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Associated factors and prognostic implications of neutropenia in individuals with HIV/AIDS.
Virol J
January 2025
Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Background: Neutropenia frequently presents as a hematological manifestation among people living with HIV/AIDS (PLWHA). This study explores the factors associated with neutropenia in PLWHA and its prognostic significance.
Methods: We conducted a retrospective case-control study of the clinical data from 780 cases of individuals living with HIV/AIDS, who were admitted to Zhongnan Hospital of Wuhan University over the period from January 2016 to September 2020.
Effect of folpet on hypoglycaemia, intestinal microbiota, and drug resistance genes in mice.
BMC Microbiol
January 2025
Shenzhen Center for Disease Control and Prevention, Shenzhen, 518055, China.
Background: Folpet is a nonspecific sulfonamide fungicide widely used to protect crops from mildew. However, the in vivo effects of folpet on glucose metabolism homeostasis, gut microbiota, and abundance of drug resistance genes remain unknown. The purpose of this study was to assess the effects of the pesticide, folpet, on glucose metabolism homeostasis, and folpet-induced changes in the intestinal microbiota and resistance genes in mice.
View Article and Find Full Text PDFJoint response of surface subsidence and strong mine earthquake under high-positioned and thick-hard strata in deep coal mine.
Sci Rep
January 2025
College of Energy and Mining Engineering, Shandong University of Science and Technology, Qingdao, 266590, China.
Multiple active mining faces and extensive excavations under thick-hard strata in deep coal mines result in frequent strong mine earthquakes, often accompanied by significant surface subsidence deformation. Understanding the specific law of surface movement and the spatiotemporal distribution response to intense mine earthquakes is crucial for effectively preventing and mitigating dynamic disasters in deep mines. Utilizing the key layer theory, the intricate strata of the Yingpanhao Coal Mine are systematically delineated, drawing upon the engineering context of working faces 2201 and 2202 within the Ordos Chemical Co.
View Article and Find Full Text PDFIntegrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility.
Nat Commun
January 2025
China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China.
It remains unclear whether the benefits of adhering to a healthy lifestyle outweigh the effects of high genetic risk on cognitive decline. We examined the association of combined lifestyle factors and genetic risk with changes in cognitive function and six specific dimensions of cognition among older adults from the Chinese Longitudinal Healthy Longevity Survey (1998-2018, n = 18,811, a subset of 6301 participants with genetic information). Compared to participants with an unfavorable lifestyle, those with a favorable lifestyle showed a 46.
View Article and Find Full Text PDFInterpretable CT Radiomics-based Machine Learning Model for Preoperative Prediction of Ki-67 Expression in Clear Cell Renal Cell Carcinoma.
Acad Radiol
January 2025
Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China (Y.X., B.X., Z.W., C.P., M.X.). Electronic address:
Rationale And Objectives: To develop and externally validate interpretable CT radiomics-based machine learning (ML) models for preoperative Ki-67 expression prediction in clear cell renal cell carcinoma (ccRCC).
Methods: 506 patients were retrospectively enrolled from three independent institutes and divided into the training (n=357) and external test (n=149) sets. Ki67 expression was determined by immunohistochemistry (IHC) and categorized into low (<15%) and high (≥15%) expression groups.
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