• Three patients with recent sequelae after Corona Virus Disease (COVID)-19 such as fatigue and myalgia of both calves underwent electrophysiological examinations, nerve conduction studies (NCS) and electromyography (EMG). NCS shows, as common elements, the presence of a partial or complete conduction block on several nerves, slightly prolonged latency of the tibial nerve, and rare or absent F-waves, all suggesting a demyelinating polyneuropathy due to SARS−COV-2. The short duration and low amplitude of the motor unit action potential with early full recruitment on interference pattern on EMG, typical for myopathy, suggest a direct action of COVID-19 on muscular fibers, especially in the lower limbs.
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http://dx.doi.org/10.1016/j.ijid.2020.11.146 | DOI Listing |
Elife
January 2025
Department of Neurology, Baylor College of Medicine, Houston, United States.
variants in children with neurodevelopmental impairment are difficult to assess due to their heterogeneity and unclear pathogenic mechanisms. We describe a child with neonatal-onset epilepsy, developmental impairment of intermediate severity, and G256W heterozygosity. Analyzing prior KCNQ2 channel cryoelectron microscopy models revealed G256 as a node of an arch-shaped non-covalent bond network linking S5, the pore turret, and the ion path.
View Article and Find Full Text PDFSkeletal Radiol
January 2025
Department of Radiology, NYU Langone Orthopedic Hospital, 301 East 17Th Street, 6Th Floor, Radiology , New York, NY, 10003, USA.
Objective: To evaluate the Neuropathy Score-Reporting and Data System (NS-RADS) MRI grading system in conjunction with electrodiagnostic (EDx) testing for radial neuropathy at the elbow.
Materials And Methods: Patients presenting between 2010 and 2023 with suspected radial neuropathy who underwent both EDx testing in the form of electromyography and nerve conduction studies and MRI within a 12-month period were evaluated. Three blinded radiologists used the NS-RADS grading system to evaluate nerve entrapment (E grades), muscle denervation (M grades) proximally within the supinator/extensor carpi radialis brevis (ECRB), and more distally within the forearm extensor muscles.
Heliyon
December 2024
Baskent University, Faculty of Medicine, Department of Biophysics, Ankara, Türkiye.
The efficacy of MitoTEMPO, a mitochondria-targeted antioxidant, in altering nerve fiber conduction properties within the sciatic nerve of streptozotocin (STZ)-induced diabetic rats, a model for diabetic neuropathy characterized by myelinated fiber atrophy and nodal abnormalities. Utilizing the STZ-induced diabetic rat model, we assessed the impact of MitoTEMPO on nerve function through compound action potential (CAP) analysis and histological evaluation. Key indicators such as maximum depolarization (MD), CAP area, and conduction velocity distribution (CVD) were measured to gauge MitoTEMPO's neuroprotective effects, alongside physical parameters like weight and blood glucose levels.
View Article and Find Full Text PDFFront Neurol
December 2024
School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
Objective: To systematically evaluate the clinical efficacy of acupuncture in the treatment of diabetic peripheral neuropathy (DPN).
Methods: Randomized controlled trial (RCT) of acupuncture for diabetic peripheral neuropathy in Chinese Knowledge Network (CNKI), Wanfang database, VIP database (VIP), PubMed, web of science, cochrane library, AMED and CINAHL were searched by computer since the establishment of the database. All publications in English and Chinese as of 30 December 2023 will be searched, without country or article type restrictions.
J Diabetes
January 2025
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Objective: To determine whether the use of herbal medicines combined with conventional treatment is more effective than conventional medication alone in improving clinical symptoms in patients with diabetic distal symmetric polyneuropathy (DSPN).
Methods: This multicenter, placebo-controlled, double-blind, randomized controlled clinical trial recruited patients from 6 clinical centers in mainland China. A total of 188 patients were randomly assigned in a 1:1 ratio to the treatment group (Tangbi Formula plus methylcobalamin) and the control group (placebo plus methylcobalamin).
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