A note on tools for prediction under uncertainty and identifiability of SIR-like dynamical systems for epidemiology.

Math Biosci

Alexander von Humboldt Professor in Mathematics for Uncertainty Quantification, RWTH Aachen University, Pontdriesch 14-16, 52062, Aachen, Germany; King Abdullah University of Science and Technology (KAUST) - Computer, Electrical and Mathematical Sciences & Engineering Division (CEMSE), Thuwal, 23955-6900, Saudi Arabia. Electronic address:

Published: February 2021

We provide an overview of the methods that can be used for prediction under uncertainty and data fitting of dynamical systems, and of the fundamental challenges that arise in this context. The focus is on SIR-like models, that are being commonly used when attempting to predict the trend of the COVID-19 pandemic. In particular, we raise a warning flag about identifiability of the parameters of SIR-like models; often, it might be hard to infer the correct values of the parameters from data, even for very simple models, making it non-trivial to use these models for meaningful predictions. Most of the points that we touch upon are actually generally valid for inverse problems in more general setups.

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Source
http://dx.doi.org/10.1016/j.mbs.2020.108514DOI Listing

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