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Soluble Transferrin Receptor during infancy and reference intervals for the Roche Cobas platform. | LitMetric

AI Article Synopsis

  • Infant iron status can be challenging to assess due to influences from infections, but soluble transferrin receptor (sTfR) may serve as a reliable biomarker.
  • The study involved measuring sTfR and CRP levels in 451 term infants at different ages to establish reference intervals for healthy growth.
  • The results showed specific sTfR reference intervals and indicated that sTfR levels do not significantly change with CRP levels in most cases, supporting its usefulness in diagnosing infant iron status.

Article Abstract

Introduction: Infant iron status assessments may be difficult to interpret due to infections. The soluble transferrin receptor (sTfR) has been suggested as a biomarker mainly unaffected by the acute phase response. Reference intervals reflecting dynamics of infant growth first year in life are not well established.

Methods: The sTfR and CRP concentrations were measured in samples from 451 term infants with the Roche Cobas platform in umbilical cord, at 48-96 hours, 4 and 12 months. Reference values were constructed as the 2.5th and 97.5th percentiles. The relationship between CRP concentrations >1 mg/L and sTfR was tested by Kendall correlation.

Results: Reference intervals for girls and boys were 2.4-9.5 mg/L at birth, 2.9-8.4 mg/L at 48-96 hours, 2.6-5.7 mg/L at 4 months and 3.0-6.3 mg/L at 12 months. No differences between sexes were observed except for at 4 months. sTfR did not covariate with CRP concentrations >1 mg/L except in 48-96 hours samples.

Conclusion: This study reports reference intervals for sTfR from birth to 12 months of age in a large group of infants in a low-risk area for iron deficiency. sTfR might add value to infant iron status diagnostics since no covariation with CRP was found at birth, at 4 months or at 12 months.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246861PMC
http://dx.doi.org/10.1111/ijlh.13391DOI Listing

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